Synthetic branched-chain analogues of distearoylphosphatidyl-choline: Structure-activity relationship in inhibiting and activating protein kinase C

A series of distearoyl-phosphatidylcholine (DSPC) analogues having various branched alkyl chains were synthesized and tested for their abilities to regulate protein kinase C (PKC). The greatest improvement (about 3-fold) in the PKC inhibitory activity over that seen for the parental lipid (i.e., DSP...

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Veröffentlicht in:	Biochemistry (Easton) 1988-01, Vol.27 (13), p.4607-4612
Hauptverfasser:	Charp, P A, Zhou, Qingzhong, Wood, MG Jr, Raynor, R L, Menger, F M, Kuo, J F
Format:	Artikel
Sprache:	eng
Schlagworte:	distearoylphosphatidylcholine
Online-Zugang:	Volltext
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