Ataxia rating scales are age‐dependent in healthy children
Aim To investigate ataxia rating scales in children for reliability and the effect of age and sex. Method Three independent neuropaediatric observers cross‐sectionally scored a set of paediatric ataxia rating scales in a group of 52 healthy children (26 males, 26 females) aged 4 to 16 years (mean ag...
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Veröffentlicht in: | Developmental medicine and child neurology 2014-06, Vol.56 (6), p.556-563 |
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creator | Brandsma, Rick Spits, Anne H Kuiper, Marieke J Lunsing, Roelinka J Burger, Huibert Kremer, Hubertus P Sival, Deborah A Barisic, N. Baxter, P. Brankovic‐Sreckovic, V. Calabrò, G.E. Catsman‐Berrevoets, C. Coo, IFM Craiu, D. Dan, B. Gburek‐Augustat, J. Kammoun‐Feki, F. Kennedy, C. Mancini, F. Mirabelli‐Badenier, M. Nemeth, A. Newton, R. Poll‐The, B.T. Steinlin, M. Synofzik, M. Topcu, M. Triki, C. Valente, E.M. |
description | Aim
To investigate ataxia rating scales in children for reliability and the effect of age and sex.
Method
Three independent neuropaediatric observers cross‐sectionally scored a set of paediatric ataxia rating scales in a group of 52 healthy children (26 males, 26 females) aged 4 to 16 years (mean age 10y 5mo SD 3y 11mo). The investigated scales involved the commonly applied International Cooperative Ataxia Rating Scale (ICARS), the Scale for Assessment and Rating of Ataxia (SARA), the Brief Ataxia Rating Scale (BARS), and PEG‐board tests. We investigated the interrelatedness between individual ataxia scales, the influence of age and sex, inter‐ and intra‐observer agreement, and test–retest reliability.
Results
Spearman's rank correlations revealed strong correlations between ICARS, SARA BARS, and PEG‐board test (all p |
doi_str_mv | 10.1111/dmcn.12369 |
format | Article |
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To investigate ataxia rating scales in children for reliability and the effect of age and sex.
Method
Three independent neuropaediatric observers cross‐sectionally scored a set of paediatric ataxia rating scales in a group of 52 healthy children (26 males, 26 females) aged 4 to 16 years (mean age 10y 5mo SD 3y 11mo). The investigated scales involved the commonly applied International Cooperative Ataxia Rating Scale (ICARS), the Scale for Assessment and Rating of Ataxia (SARA), the Brief Ataxia Rating Scale (BARS), and PEG‐board tests. We investigated the interrelatedness between individual ataxia scales, the influence of age and sex, inter‐ and intra‐observer agreement, and test–retest reliability.
Results
Spearman's rank correlations revealed strong correlations between ICARS, SARA BARS, and PEG‐board test (all p<0.001). ICARS, SARA, BARS and PEG‐board test outcomes were age‐dependent until 12.5, 10, 11, and 11.5 years of age respectively. Intraclass correlation coefficients (ICCs) varied between moderate and almost perfect (interobserver agreement: 0.85, 0.72, and 0.69; intraobserver agreement: 0.92, 0.94, and 0.70; and test–retest reliability: 0.95, 0.50, and 0.71; for ICARS, SARA, and BARS respectively). Interobserver variability decreased after the sixth year of life.
Interpretation
In healthy children, ataxia rating scales are reliable, but should include age‐dependent interpretation in children up to 12 years of age. To enable longitudinal interpretation of quantitative ataxia rating scales in children, European paediatric normative values are necessary.
What this paper adds
In children, ataxia rating scales can be reliably assessed.
Ataxia rating scales are age‐dependent until 12 years of age.
ICARS, SARA, BARS and the nine‐hole PEG‐board test are correlated.
This article is commented on by Mink on pages 511–512 of this issue.</description><identifier>ISSN: 0012-1622</identifier><identifier>EISSN: 1469-8749</identifier><identifier>DOI: 10.1111/dmcn.12369</identifier><identifier>PMID: 24392880</identifier><language>eng</language><publisher>England</publisher><subject>Achievement ; Adolescent ; Age Factors ; Ataxia - classification ; Ataxia - diagnosis ; Ataxia - epidemiology ; Child ; Child, Preschool ; Cross-Sectional Studies ; Disability Evaluation ; Female ; Humans ; Male ; Neurologic Examination - statistics & numerical data ; Neuropsychological Tests - statistics & numerical data ; Observer Variation ; Pilot Projects ; Psychomotor Disorders - classification ; Psychomotor Disorders - diagnosis ; Psychomotor Disorders - epidemiology ; Reference Values ; Sports ; Statistics as Topic</subject><ispartof>Developmental medicine and child neurology, 2014-06, Vol.56 (6), p.556-563</ispartof><rights>2014 Mac Keith Press</rights><rights>2014 Mac Keith Press.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4319-c29eba0ba635c01b89d77a54aa92f0204140a119c146795c2a5aefa626f237a83</citedby><cites>FETCH-LOGICAL-c4319-c29eba0ba635c01b89d77a54aa92f0204140a119c146795c2a5aefa626f237a83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fdmcn.12369$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fdmcn.12369$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,1428,27905,27906,45555,45556,46390,46814</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24392880$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Brandsma, Rick</creatorcontrib><creatorcontrib>Spits, Anne H</creatorcontrib><creatorcontrib>Kuiper, Marieke J</creatorcontrib><creatorcontrib>Lunsing, Roelinka J</creatorcontrib><creatorcontrib>Burger, Huibert</creatorcontrib><creatorcontrib>Kremer, Hubertus P</creatorcontrib><creatorcontrib>Sival, Deborah A</creatorcontrib><creatorcontrib>Barisic, N.</creatorcontrib><creatorcontrib>Baxter, P.</creatorcontrib><creatorcontrib>Brankovic‐Sreckovic, V.</creatorcontrib><creatorcontrib>Calabrò, G.E.</creatorcontrib><creatorcontrib>Catsman‐Berrevoets, C.</creatorcontrib><creatorcontrib>Coo, IFM</creatorcontrib><creatorcontrib>Craiu, D.</creatorcontrib><creatorcontrib>Dan, B.</creatorcontrib><creatorcontrib>Gburek‐Augustat, J.</creatorcontrib><creatorcontrib>Kammoun‐Feki, F.</creatorcontrib><creatorcontrib>Kennedy, C.</creatorcontrib><creatorcontrib>Mancini, F.</creatorcontrib><creatorcontrib>Mirabelli‐Badenier, M.</creatorcontrib><creatorcontrib>Nemeth, A.</creatorcontrib><creatorcontrib>Newton, R.</creatorcontrib><creatorcontrib>Poll‐The, B.T.</creatorcontrib><creatorcontrib>Steinlin, M.</creatorcontrib><creatorcontrib>Synofzik, M.</creatorcontrib><creatorcontrib>Topcu, M.</creatorcontrib><creatorcontrib>Triki, C.</creatorcontrib><creatorcontrib>Valente, E.M.</creatorcontrib><creatorcontrib>Childhood Ataxia and Cerebellar Group</creatorcontrib><creatorcontrib>The Childhood Ataxia and Cerebellar Group</creatorcontrib><title>Ataxia rating scales are age‐dependent in healthy children</title><title>Developmental medicine and child neurology</title><addtitle>Dev Med Child Neurol</addtitle><description>Aim
To investigate ataxia rating scales in children for reliability and the effect of age and sex.
Method
Three independent neuropaediatric observers cross‐sectionally scored a set of paediatric ataxia rating scales in a group of 52 healthy children (26 males, 26 females) aged 4 to 16 years (mean age 10y 5mo SD 3y 11mo). The investigated scales involved the commonly applied International Cooperative Ataxia Rating Scale (ICARS), the Scale for Assessment and Rating of Ataxia (SARA), the Brief Ataxia Rating Scale (BARS), and PEG‐board tests. We investigated the interrelatedness between individual ataxia scales, the influence of age and sex, inter‐ and intra‐observer agreement, and test–retest reliability.
Results
Spearman's rank correlations revealed strong correlations between ICARS, SARA BARS, and PEG‐board test (all p<0.001). ICARS, SARA, BARS and PEG‐board test outcomes were age‐dependent until 12.5, 10, 11, and 11.5 years of age respectively. Intraclass correlation coefficients (ICCs) varied between moderate and almost perfect (interobserver agreement: 0.85, 0.72, and 0.69; intraobserver agreement: 0.92, 0.94, and 0.70; and test–retest reliability: 0.95, 0.50, and 0.71; for ICARS, SARA, and BARS respectively). Interobserver variability decreased after the sixth year of life.
Interpretation
In healthy children, ataxia rating scales are reliable, but should include age‐dependent interpretation in children up to 12 years of age. To enable longitudinal interpretation of quantitative ataxia rating scales in children, European paediatric normative values are necessary.
What this paper adds
In children, ataxia rating scales can be reliably assessed.
Ataxia rating scales are age‐dependent until 12 years of age.
ICARS, SARA, BARS and the nine‐hole PEG‐board test are correlated.
This article is commented on by Mink on pages 511–512 of this issue.</description><subject>Achievement</subject><subject>Adolescent</subject><subject>Age Factors</subject><subject>Ataxia - classification</subject><subject>Ataxia - diagnosis</subject><subject>Ataxia - epidemiology</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Cross-Sectional Studies</subject><subject>Disability Evaluation</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Neurologic Examination - statistics & numerical data</subject><subject>Neuropsychological Tests - statistics & numerical data</subject><subject>Observer Variation</subject><subject>Pilot Projects</subject><subject>Psychomotor Disorders - classification</subject><subject>Psychomotor Disorders - diagnosis</subject><subject>Psychomotor Disorders - epidemiology</subject><subject>Reference Values</subject><subject>Sports</subject><subject>Statistics as Topic</subject><issn>0012-1622</issn><issn>1469-8749</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kD1Ow0AQRlcIREKg4QDIJUJymP3x2ivRROFXCtBAvRqvx4mR4wSvI0jHETgjJ8HBgZJppnl6-vQYO-Yw5O2dZ3NXDbmQ2uywPlfahEmszC7rA3ARci1Ejx14_wIAUkdqn_WEkkYkCfTZxajB9wKDGpuimgbeYUk-wJoCnNLXx2dGS6oyqpqgqIIZYdnM1oGbFWVWU3XI9nIsPR1t_4A9X189jW_DyePN3Xg0CZ2S3IROGEoRUtQycsDTxGRxjJFCNCIHAYorQM6Na7fHJnICI6QctdC5kDEmcsBOO--yXryuyDd2XnhHZYkVLVbe8khIBTGAbtGzDnX1wvuacrusiznWa8vBbmrZTS37U6uFT7beVTqn7A_9zdMCvAPeipLW_6js5f34oZN-A_zndEU</recordid><startdate>201406</startdate><enddate>201406</enddate><creator>Brandsma, Rick</creator><creator>Spits, Anne H</creator><creator>Kuiper, Marieke J</creator><creator>Lunsing, Roelinka J</creator><creator>Burger, Huibert</creator><creator>Kremer, Hubertus P</creator><creator>Sival, Deborah A</creator><creator>Barisic, N.</creator><creator>Baxter, P.</creator><creator>Brankovic‐Sreckovic, V.</creator><creator>Calabrò, G.E.</creator><creator>Catsman‐Berrevoets, C.</creator><creator>Coo, IFM</creator><creator>Craiu, D.</creator><creator>Dan, B.</creator><creator>Gburek‐Augustat, J.</creator><creator>Kammoun‐Feki, F.</creator><creator>Kennedy, C.</creator><creator>Mancini, F.</creator><creator>Mirabelli‐Badenier, M.</creator><creator>Nemeth, A.</creator><creator>Newton, R.</creator><creator>Poll‐The, B.T.</creator><creator>Steinlin, M.</creator><creator>Synofzik, M.</creator><creator>Topcu, M.</creator><creator>Triki, C.</creator><creator>Valente, E.M.</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201406</creationdate><title>Ataxia rating scales are age‐dependent in healthy children</title><author>Brandsma, Rick ; Spits, Anne H ; Kuiper, Marieke J ; Lunsing, Roelinka J ; Burger, Huibert ; Kremer, Hubertus P ; Sival, Deborah A ; Barisic, N. ; Baxter, P. ; Brankovic‐Sreckovic, V. ; Calabrò, G.E. ; Catsman‐Berrevoets, C. ; Coo, IFM ; Craiu, D. ; Dan, B. ; Gburek‐Augustat, J. ; Kammoun‐Feki, F. ; Kennedy, C. ; Mancini, F. ; Mirabelli‐Badenier, M. ; Nemeth, A. ; Newton, R. ; Poll‐The, B.T. ; Steinlin, M. ; Synofzik, M. ; Topcu, M. ; Triki, C. ; Valente, E.M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4319-c29eba0ba635c01b89d77a54aa92f0204140a119c146795c2a5aefa626f237a83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Achievement</topic><topic>Adolescent</topic><topic>Age Factors</topic><topic>Ataxia - classification</topic><topic>Ataxia - diagnosis</topic><topic>Ataxia - epidemiology</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Cross-Sectional Studies</topic><topic>Disability Evaluation</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Neurologic Examination - statistics & numerical data</topic><topic>Neuropsychological Tests - statistics & numerical data</topic><topic>Observer Variation</topic><topic>Pilot Projects</topic><topic>Psychomotor Disorders - classification</topic><topic>Psychomotor Disorders - diagnosis</topic><topic>Psychomotor Disorders - epidemiology</topic><topic>Reference Values</topic><topic>Sports</topic><topic>Statistics as Topic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Brandsma, Rick</creatorcontrib><creatorcontrib>Spits, Anne H</creatorcontrib><creatorcontrib>Kuiper, Marieke J</creatorcontrib><creatorcontrib>Lunsing, Roelinka J</creatorcontrib><creatorcontrib>Burger, Huibert</creatorcontrib><creatorcontrib>Kremer, Hubertus P</creatorcontrib><creatorcontrib>Sival, Deborah A</creatorcontrib><creatorcontrib>Barisic, N.</creatorcontrib><creatorcontrib>Baxter, P.</creatorcontrib><creatorcontrib>Brankovic‐Sreckovic, V.</creatorcontrib><creatorcontrib>Calabrò, G.E.</creatorcontrib><creatorcontrib>Catsman‐Berrevoets, C.</creatorcontrib><creatorcontrib>Coo, IFM</creatorcontrib><creatorcontrib>Craiu, D.</creatorcontrib><creatorcontrib>Dan, B.</creatorcontrib><creatorcontrib>Gburek‐Augustat, J.</creatorcontrib><creatorcontrib>Kammoun‐Feki, F.</creatorcontrib><creatorcontrib>Kennedy, C.</creatorcontrib><creatorcontrib>Mancini, F.</creatorcontrib><creatorcontrib>Mirabelli‐Badenier, M.</creatorcontrib><creatorcontrib>Nemeth, A.</creatorcontrib><creatorcontrib>Newton, R.</creatorcontrib><creatorcontrib>Poll‐The, B.T.</creatorcontrib><creatorcontrib>Steinlin, M.</creatorcontrib><creatorcontrib>Synofzik, M.</creatorcontrib><creatorcontrib>Topcu, M.</creatorcontrib><creatorcontrib>Triki, C.</creatorcontrib><creatorcontrib>Valente, E.M.</creatorcontrib><creatorcontrib>Childhood Ataxia and Cerebellar Group</creatorcontrib><creatorcontrib>The Childhood Ataxia and Cerebellar Group</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Developmental medicine and child neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Brandsma, Rick</au><au>Spits, Anne H</au><au>Kuiper, Marieke J</au><au>Lunsing, Roelinka J</au><au>Burger, Huibert</au><au>Kremer, Hubertus P</au><au>Sival, Deborah A</au><au>Barisic, N.</au><au>Baxter, P.</au><au>Brankovic‐Sreckovic, V.</au><au>Calabrò, G.E.</au><au>Catsman‐Berrevoets, C.</au><au>Coo, IFM</au><au>Craiu, D.</au><au>Dan, B.</au><au>Gburek‐Augustat, J.</au><au>Kammoun‐Feki, F.</au><au>Kennedy, C.</au><au>Mancini, F.</au><au>Mirabelli‐Badenier, M.</au><au>Nemeth, A.</au><au>Newton, R.</au><au>Poll‐The, B.T.</au><au>Steinlin, M.</au><au>Synofzik, M.</au><au>Topcu, M.</au><au>Triki, C.</au><au>Valente, E.M.</au><aucorp>Childhood Ataxia and Cerebellar Group</aucorp><aucorp>The Childhood Ataxia and Cerebellar Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ataxia rating scales are age‐dependent in healthy children</atitle><jtitle>Developmental medicine and child neurology</jtitle><addtitle>Dev Med Child Neurol</addtitle><date>2014-06</date><risdate>2014</risdate><volume>56</volume><issue>6</issue><spage>556</spage><epage>563</epage><pages>556-563</pages><issn>0012-1622</issn><eissn>1469-8749</eissn><abstract>Aim
To investigate ataxia rating scales in children for reliability and the effect of age and sex.
Method
Three independent neuropaediatric observers cross‐sectionally scored a set of paediatric ataxia rating scales in a group of 52 healthy children (26 males, 26 females) aged 4 to 16 years (mean age 10y 5mo SD 3y 11mo). The investigated scales involved the commonly applied International Cooperative Ataxia Rating Scale (ICARS), the Scale for Assessment and Rating of Ataxia (SARA), the Brief Ataxia Rating Scale (BARS), and PEG‐board tests. We investigated the interrelatedness between individual ataxia scales, the influence of age and sex, inter‐ and intra‐observer agreement, and test–retest reliability.
Results
Spearman's rank correlations revealed strong correlations between ICARS, SARA BARS, and PEG‐board test (all p<0.001). ICARS, SARA, BARS and PEG‐board test outcomes were age‐dependent until 12.5, 10, 11, and 11.5 years of age respectively. Intraclass correlation coefficients (ICCs) varied between moderate and almost perfect (interobserver agreement: 0.85, 0.72, and 0.69; intraobserver agreement: 0.92, 0.94, and 0.70; and test–retest reliability: 0.95, 0.50, and 0.71; for ICARS, SARA, and BARS respectively). Interobserver variability decreased after the sixth year of life.
Interpretation
In healthy children, ataxia rating scales are reliable, but should include age‐dependent interpretation in children up to 12 years of age. To enable longitudinal interpretation of quantitative ataxia rating scales in children, European paediatric normative values are necessary.
What this paper adds
In children, ataxia rating scales can be reliably assessed.
Ataxia rating scales are age‐dependent until 12 years of age.
ICARS, SARA, BARS and the nine‐hole PEG‐board test are correlated.
This article is commented on by Mink on pages 511–512 of this issue.</abstract><cop>England</cop><pmid>24392880</pmid><doi>10.1111/dmcn.12369</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Achievement Adolescent Age Factors Ataxia - classification Ataxia - diagnosis Ataxia - epidemiology Child Child, Preschool Cross-Sectional Studies Disability Evaluation Female Humans Male Neurologic Examination - statistics & numerical data Neuropsychological Tests - statistics & numerical data Observer Variation Pilot Projects Psychomotor Disorders - classification Psychomotor Disorders - diagnosis Psychomotor Disorders - epidemiology Reference Values Sports Statistics as Topic |
title | Ataxia rating scales are age‐dependent in healthy children |
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