Imatinib Mesylate Attenuates Myocardial Remodeling Through Inhibition of Platelet-Derived Growth Factor and Transforming Growth Factor Activation in a Rat Model of Hypertension

Imatinib mesylate is a specific tyrosine kinase inhibitor that may block the platelet-derived growth factor and transforming growth factor pathways. These pathways are known to provoke fibroblast activation. We evaluated whether imatinib, by inhibiting these pathways, prevents diastolic dysfunction...

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Veröffentlicht in:	Hypertension (Dallas, Tex. 1979) Tex. 1979), 2014-06, Vol.63 (6), p.1228-1234
Hauptverfasser:	JANG, Sung-Won, IHM, Sang-Hyun, CHOO, Eun-Ho, KIM, Ok-Ran, KIYUK CHANG, PARK, Chan-Seok, KIM, Hee-Yeol, SEUNG, Ki-Bae
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arterial hypertension. Arterial hypotension Benzamides - pharmacology Biological and medical sciences Blood and lymphatic vessels Blotting, Western Cardiology. Vascular system Collagen Type I - genetics Collagen Type III - genetics Fibroblasts - drug effects Fibroblasts - metabolism Fibrosis - genetics Fibrosis - metabolism Fibrosis - prevention & control Gene Expression - drug effects Hypertension - genetics Hypertension - metabolism Hypertension - physiopathology Hypertrophy, Left Ventricular - genetics Hypertrophy, Left Ventricular - metabolism Hypertrophy, Left Ventricular - prevention & control Imatinib Mesylate Male Medical sciences Myocardium - metabolism Myocardium - pathology Phosphorylation - drug effects Piperazines - pharmacology Platelet-Derived Growth Factor - metabolism Platelet-Derived Growth Factor - pharmacology Protein Kinase Inhibitors - pharmacology Proto-Oncogene Proteins c-abl - metabolism Pyrimidines - pharmacology Rats Rats, Inbred SHR Rats, Inbred WKY Receptors, Platelet-Derived Growth Factor - metabolism Reverse Transcriptase Polymerase Chain Reaction Transforming Growth Factor beta1 - genetics Transforming Growth Factor beta1 - metabolism Transforming Growth Factor beta1 - pharmacology Ventricular Remodeling - drug effects
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