Tumor‐derived microparticles induce bone marrow‐derived cell mobilization and tumor homing: A process regulated by osteopontin

Acute chemotherapy can induce rapid bone‐marrow derived pro‐angiogenic cell (BMDC) mobilization and tumor homing, contributing to tumor regrowth. To study the contribution of tumor cells to tumor regrowth following therapy, we focused on tumor‐derived microparticles (TMPs). EMT/6 murine‐mammary carc...

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Veröffentlicht in:	International journal of cancer 2014-07, Vol.135 (2), p.270-281
Hauptverfasser:	Fremder, Ella, Munster, Michal, Aharon, Anat, Miller, Valeria, Gingis‐Velitski, Svetlana, Voloshin, Tali, Alishekevitz, Dror, Bril, Rotem, Scherer, Stefan J., Loven, David, Brenner, Benjamin, Shaked, Yuval
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Animals Antineoplastic Agents - pharmacology Biological and medical sciences Bone marrow Bone Marrow Cells - metabolism Bone Marrow Cells - pathology bone marrow derived cells Breast Neoplasms - blood supply Breast Neoplasms - metabolism Breast Neoplasms - pathology Cancer Cell Line, Tumor Cell Movement - drug effects Cell-Derived Microparticles - metabolism Chemotherapy Cytotoxicity Female Flow Cytometry Gene Knockdown Techniques Humans Immunohistochemistry Medical research Medical sciences Mice Mice, Inbred BALB C microparticles Neovascularization, Pathologic - metabolism Neovascularization, Pathologic - pathology Osteopontin - metabolism Paclitaxel - pharmacology Rodents Tumors
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