Development of an Activity-Based Probe and In Silico Design Reveal Highly Selective Inhibitors for Diacylglycerol Lipase-α in Brain
A model method: A strategy that combines a knowledge‐based in silico design approach and the development of novel activity‐based probes (ABPs) for the detection of endogenous diacylglycerol lipase‐α (DAGL‐α) is presented. This approach resulted in the rapid identification of new DAGL‐α inhibitors wi...
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| Veröffentlicht in: | Angewandte Chemie International Edition 2013-11, Vol.52 (46), p.12081-12085 |
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| creator | Baggelaar, Marc P. Janssen, Freek J. van Esbroeck, Annelot C. M. den Dulk, Hans Allarà, Marco Hoogendoorn, Sascha McGuire, Ross Florea, Bogdan I. Meeuwenoord, Nico van den Elst, Hans van der Marel, Gijsbert A. Brouwer, Jaap Di Marzo, Vincenzo Overkleeft, Herman S. van der Stelt, Mario |
| description | A model method: A strategy that combines a knowledge‐based in silico design approach and the development of novel activity‐based probes (ABPs) for the detection of endogenous diacylglycerol lipase‐α (DAGL‐α) is presented. This approach resulted in the rapid identification of new DAGL‐α inhibitors with high selectivity in the brain proteome. ABPP=activity‐based protein profiling. |
| doi_str_mv | 10.1002/anie.201306295 |
| format | Article |
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M. ; den Dulk, Hans ; Allarà, Marco ; Hoogendoorn, Sascha ; McGuire, Ross ; Florea, Bogdan I. ; Meeuwenoord, Nico ; van den Elst, Hans ; van der Marel, Gijsbert A. ; Brouwer, Jaap ; Di Marzo, Vincenzo ; Overkleeft, Herman S. ; van der Stelt, Mario</creator><creatorcontrib>Baggelaar, Marc P. ; Janssen, Freek J. ; van Esbroeck, Annelot C. M. ; den Dulk, Hans ; Allarà, Marco ; Hoogendoorn, Sascha ; McGuire, Ross ; Florea, Bogdan I. ; Meeuwenoord, Nico ; van den Elst, Hans ; van der Marel, Gijsbert A. ; Brouwer, Jaap ; Di Marzo, Vincenzo ; Overkleeft, Herman S. ; van der Stelt, Mario</creatorcontrib><description>A model method: A strategy that combines a knowledge‐based in silico design approach and the development of novel activity‐based probes (ABPs) for the detection of endogenous diacylglycerol lipase‐α (DAGL‐α) is presented. This approach resulted in the rapid identification of new DAGL‐α inhibitors with high selectivity in the brain proteome. ABPP=activity‐based protein profiling.</description><identifier>ISSN: 1433-7851</identifier><identifier>EISSN: 1521-3773</identifier><identifier>DOI: 10.1002/anie.201306295</identifier><identifier>PMID: 24173880</identifier><language>eng</language><publisher>Weinheim: WILEY-VCH Verlag</publisher><subject>activity-based probe ; Animals ; Arachidonic Acids - metabolism ; Binding Sites ; Brain - enzymology ; Brain - metabolism ; Cell Membrane - metabolism ; drug discovery ; endocannabinoid ; Endocannabinoids - metabolism ; Enzyme Inhibitors - chemistry ; Enzyme Inhibitors - metabolism ; Glycerides - metabolism ; HEK293 Cells ; Humans ; hydrolases ; Lipoprotein Lipase - antagonists & inhibitors ; Lipoprotein Lipase - genetics ; Lipoprotein Lipase - metabolism ; Mice ; Protein Binding ; Protein Structure, Tertiary ; Proteome ; proteomics ; Structure-Activity Relationship</subject><ispartof>Angewandte Chemie International Edition, 2013-11, Vol.52 (46), p.12081-12085</ispartof><rights>Copyright © 2013 WILEY‐VCH Verlag GmbH & Co. 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| identifier | ISSN: 1433-7851 |
| ispartof | Angewandte Chemie International Edition, 2013-11, Vol.52 (46), p.12081-12085 |
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| subjects | activity-based probe Animals Arachidonic Acids - metabolism Binding Sites Brain - enzymology Brain - metabolism Cell Membrane - metabolism drug discovery endocannabinoid Endocannabinoids - metabolism Enzyme Inhibitors - chemistry Enzyme Inhibitors - metabolism Glycerides - metabolism HEK293 Cells Humans hydrolases Lipoprotein Lipase - antagonists & inhibitors Lipoprotein Lipase - genetics Lipoprotein Lipase - metabolism Mice Protein Binding Protein Structure, Tertiary Proteome proteomics Structure-Activity Relationship |
| title | Development of an Activity-Based Probe and In Silico Design Reveal Highly Selective Inhibitors for Diacylglycerol Lipase-α in Brain |
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