Impact of autonomic and self-regulation on cancer-related fatigue and distress in breast cancer patients – a prospective observational study
Purpose Cancer-related fatigue (CRF) has a major impact on the quality of life in breast cancer patients (BC). So far, only a few prospective studies have investigated the effect of adaptive salutogenic mechanisms on CRF. The aim of our study was to evaluate the possible prospective influence of aut...
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| Veröffentlicht in: | Journal of cancer survivorship 2014-06, Vol.8 (2), p.319-328 |
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| creator | Kröz, M. Reif, M. Bartsch, C. Heckmann, C. Zerm, R. Schad, F. Girke, M. |
| description | Purpose
Cancer-related fatigue (CRF) has a major impact on the quality of life in breast cancer patients (BC). So far, only a few prospective studies have investigated the effect of adaptive salutogenic mechanisms on CRF. The aim of our study was to evaluate the possible prospective influence of autonomic Regulation (aR) and self-regulation (SR) on CRF and distress in long-term survivors.
Methods
95 BC and 80 healthy female controls (C) had been included in the observational study between 2000 and 2001 and completed the questionnaires on aR, SR and Hospital Anxiety and Depression Scale (HADS). Of these, 62 BC, and 58 C participated in the re-evaluation 6.6 years later: 16 participants were deceased (14 BC and 2 C). During follow-up, participants were requested to answer questions involving (Cancer Fatigue Scales) CFS-D, aR, SR and HADS. Multiple regression analysis was used to evaluate the influence of aR, SR, age, Charlson co-morbidity-index and diagnosis on CFS-D and HADS, and to select further potentially relevant factors.
Results
High aR values showed significant effects, namely inverse relationships with CFS-D, cognitive fatigue, anxiety and depression. SR showed a reduced influence on anxiety and depression (all p |
| doi_str_mv | 10.1007/s11764-013-0314-6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1523401434</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3296593381</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-59388c845f73476daf5019abf7e2f4c0ea5f2d7bb15e83aa88b70b6d8bd788d63</originalsourceid><addsrcrecordid>eNp1kcuKFjEQhRtRnHH0AdxIwI2b1lw76aUMXgYG3Og65FL56aFvptIDs_MJZuMb-iTmvziIIAQSqr6cOsVpmpeMvmWU6nfImO5kS5loqWCy7R4156wXvOW8048f3qo_a54h3lCqeM_40-aMS65Er-R5c381rS4UsiTitrLMyzQE4uZIEMbUZthtoyvDMpN6gpsD5FqsJYgk1cZugwMdBywZEMkwE5_BYTnRZK0UzAXJrx8_iSNrXnCFUIZbIItHyLcHeTcSLFu8e948SW5EeHG6L5pvHz98vfzcXn_5dHX5_roNQvPSql4YE4xUSQupu-iSoqx3PmngSQYKTiUetfdMgRHOGeM19V00PmpjYicumjdH3ern-wZY7DRggHF0MywbWqa4kJRJISv6-h_0ZtlydXygmOm1ZLxS7EiFuiBmSHbNw-TynWXU7sOyx7BsDcvuw7J7E69OypufID78-JNOBfgRwNqad5D_Gv1f1d-HUqJ-</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1521897412</pqid></control><display><type>article</type><title>Impact of autonomic and self-regulation on cancer-related fatigue and distress in breast cancer patients – a prospective observational study</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Kröz, M. ; Reif, M. ; Bartsch, C. ; Heckmann, C. ; Zerm, R. ; Schad, F. ; Girke, M.</creator><creatorcontrib>Kröz, M. ; Reif, M. ; Bartsch, C. ; Heckmann, C. ; Zerm, R. ; Schad, F. ; Girke, M.</creatorcontrib><description>Purpose
Cancer-related fatigue (CRF) has a major impact on the quality of life in breast cancer patients (BC). So far, only a few prospective studies have investigated the effect of adaptive salutogenic mechanisms on CRF. The aim of our study was to evaluate the possible prospective influence of autonomic Regulation (aR) and self-regulation (SR) on CRF and distress in long-term survivors.
Methods
95 BC and 80 healthy female controls (C) had been included in the observational study between 2000 and 2001 and completed the questionnaires on aR, SR and Hospital Anxiety and Depression Scale (HADS). Of these, 62 BC, and 58 C participated in the re-evaluation 6.6 years later: 16 participants were deceased (14 BC and 2 C). During follow-up, participants were requested to answer questions involving (Cancer Fatigue Scales) CFS-D, aR, SR and HADS. Multiple regression analysis was used to evaluate the influence of aR, SR, age, Charlson co-morbidity-index and diagnosis on CFS-D and HADS, and to select further potentially relevant factors.
Results
High aR values showed significant effects, namely inverse relationships with CFS-D, cognitive fatigue, anxiety and depression. SR showed a reduced influence on anxiety and depression (all p < 0.05).
Conclusions
Autonomic regulation might have an independent, reductive influence on global fatigue, cognitive fatigue and – together with self-regulation – it seems to have a protective influence on anxiety and depression. The connection between these parameters is still unclear and awaits further evaluation.
Implication for Cancer Survivors
AR seems to be a prognostic factor in breast cancer survivors, capable of reducing cancer-related fatigue and self-regulation distress as well. Further research is necessary in order to show how aR can be improved by therapeutic interventions.</description><identifier>ISSN: 1932-2259</identifier><identifier>EISSN: 1932-2267</identifier><identifier>DOI: 10.1007/s11764-013-0314-6</identifier><identifier>PMID: 24253954</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Adult ; Aged ; Anxiety - physiopathology ; Breast cancer ; Cognition & reasoning ; Depression - physiopathology ; Emotions ; Fatigue ; Fatigue - physiopathology ; Female ; Health Informatics ; Health Promotion and Disease Prevention ; Humans ; Medicine ; Medicine & Public Health ; Middle Aged ; Neoplasms - mortality ; Neoplasms - physiopathology ; Neoplasms - psychology ; Oncology ; Primary Care Medicine ; Prospective Studies ; Public Health ; Quality of Life ; Quality of Life Research ; Surveys and Questionnaires ; Survivor ; Survivors</subject><ispartof>Journal of cancer survivorship, 2014-06, Vol.8 (2), p.319-328</ispartof><rights>Springer Science+Business Media New York 2013</rights><rights>Springer Science+Business Media New York 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-59388c845f73476daf5019abf7e2f4c0ea5f2d7bb15e83aa88b70b6d8bd788d63</citedby><cites>FETCH-LOGICAL-c372t-59388c845f73476daf5019abf7e2f4c0ea5f2d7bb15e83aa88b70b6d8bd788d63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11764-013-0314-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11764-013-0314-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24253954$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kröz, M.</creatorcontrib><creatorcontrib>Reif, M.</creatorcontrib><creatorcontrib>Bartsch, C.</creatorcontrib><creatorcontrib>Heckmann, C.</creatorcontrib><creatorcontrib>Zerm, R.</creatorcontrib><creatorcontrib>Schad, F.</creatorcontrib><creatorcontrib>Girke, M.</creatorcontrib><title>Impact of autonomic and self-regulation on cancer-related fatigue and distress in breast cancer patients – a prospective observational study</title><title>Journal of cancer survivorship</title><addtitle>J Cancer Surviv</addtitle><addtitle>J Cancer Surviv</addtitle><description>Purpose
Cancer-related fatigue (CRF) has a major impact on the quality of life in breast cancer patients (BC). So far, only a few prospective studies have investigated the effect of adaptive salutogenic mechanisms on CRF. The aim of our study was to evaluate the possible prospective influence of autonomic Regulation (aR) and self-regulation (SR) on CRF and distress in long-term survivors.
Methods
95 BC and 80 healthy female controls (C) had been included in the observational study between 2000 and 2001 and completed the questionnaires on aR, SR and Hospital Anxiety and Depression Scale (HADS). Of these, 62 BC, and 58 C participated in the re-evaluation 6.6 years later: 16 participants were deceased (14 BC and 2 C). During follow-up, participants were requested to answer questions involving (Cancer Fatigue Scales) CFS-D, aR, SR and HADS. Multiple regression analysis was used to evaluate the influence of aR, SR, age, Charlson co-morbidity-index and diagnosis on CFS-D and HADS, and to select further potentially relevant factors.
Results
High aR values showed significant effects, namely inverse relationships with CFS-D, cognitive fatigue, anxiety and depression. SR showed a reduced influence on anxiety and depression (all p < 0.05).
Conclusions
Autonomic regulation might have an independent, reductive influence on global fatigue, cognitive fatigue and – together with self-regulation – it seems to have a protective influence on anxiety and depression. The connection between these parameters is still unclear and awaits further evaluation.
Implication for Cancer Survivors
AR seems to be a prognostic factor in breast cancer survivors, capable of reducing cancer-related fatigue and self-regulation distress as well. Further research is necessary in order to show how aR can be improved by therapeutic interventions.</description><subject>Adult</subject><subject>Aged</subject><subject>Anxiety - physiopathology</subject><subject>Breast cancer</subject><subject>Cognition & reasoning</subject><subject>Depression - physiopathology</subject><subject>Emotions</subject><subject>Fatigue</subject><subject>Fatigue - physiopathology</subject><subject>Female</subject><subject>Health Informatics</subject><subject>Health Promotion and Disease Prevention</subject><subject>Humans</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neoplasms - mortality</subject><subject>Neoplasms - physiopathology</subject><subject>Neoplasms - psychology</subject><subject>Oncology</subject><subject>Primary Care Medicine</subject><subject>Prospective Studies</subject><subject>Public Health</subject><subject>Quality of Life</subject><subject>Quality of Life Research</subject><subject>Surveys and Questionnaires</subject><subject>Survivor</subject><subject>Survivors</subject><issn>1932-2259</issn><issn>1932-2267</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1kcuKFjEQhRtRnHH0AdxIwI2b1lw76aUMXgYG3Og65FL56aFvptIDs_MJZuMb-iTmvziIIAQSqr6cOsVpmpeMvmWU6nfImO5kS5loqWCy7R4156wXvOW8048f3qo_a54h3lCqeM_40-aMS65Er-R5c381rS4UsiTitrLMyzQE4uZIEMbUZthtoyvDMpN6gpsD5FqsJYgk1cZugwMdBywZEMkwE5_BYTnRZK0UzAXJrx8_iSNrXnCFUIZbIItHyLcHeTcSLFu8e948SW5EeHG6L5pvHz98vfzcXn_5dHX5_roNQvPSql4YE4xUSQupu-iSoqx3PmngSQYKTiUetfdMgRHOGeM19V00PmpjYicumjdH3ern-wZY7DRggHF0MywbWqa4kJRJISv6-h_0ZtlydXygmOm1ZLxS7EiFuiBmSHbNw-TynWXU7sOyx7BsDcvuw7J7E69OypufID78-JNOBfgRwNqad5D_Gv1f1d-HUqJ-</recordid><startdate>20140601</startdate><enddate>20140601</enddate><creator>Kröz, M.</creator><creator>Reif, M.</creator><creator>Bartsch, C.</creator><creator>Heckmann, C.</creator><creator>Zerm, R.</creator><creator>Schad, F.</creator><creator>Girke, M.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20140601</creationdate><title>Impact of autonomic and self-regulation on cancer-related fatigue and distress in breast cancer patients – a prospective observational study</title><author>Kröz, M. ; Reif, M. ; Bartsch, C. ; Heckmann, C. ; Zerm, R. ; Schad, F. ; Girke, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-59388c845f73476daf5019abf7e2f4c0ea5f2d7bb15e83aa88b70b6d8bd788d63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Anxiety - physiopathology</topic><topic>Breast cancer</topic><topic>Cognition & reasoning</topic><topic>Depression - physiopathology</topic><topic>Emotions</topic><topic>Fatigue</topic><topic>Fatigue - physiopathology</topic><topic>Female</topic><topic>Health Informatics</topic><topic>Health Promotion and Disease Prevention</topic><topic>Humans</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Neoplasms - mortality</topic><topic>Neoplasms - physiopathology</topic><topic>Neoplasms - psychology</topic><topic>Oncology</topic><topic>Primary Care Medicine</topic><topic>Prospective Studies</topic><topic>Public Health</topic><topic>Quality of Life</topic><topic>Quality of Life Research</topic><topic>Surveys and Questionnaires</topic><topic>Survivor</topic><topic>Survivors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kröz, M.</creatorcontrib><creatorcontrib>Reif, M.</creatorcontrib><creatorcontrib>Bartsch, C.</creatorcontrib><creatorcontrib>Heckmann, C.</creatorcontrib><creatorcontrib>Zerm, R.</creatorcontrib><creatorcontrib>Schad, F.</creatorcontrib><creatorcontrib>Girke, M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cancer survivorship</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kröz, M.</au><au>Reif, M.</au><au>Bartsch, C.</au><au>Heckmann, C.</au><au>Zerm, R.</au><au>Schad, F.</au><au>Girke, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of autonomic and self-regulation on cancer-related fatigue and distress in breast cancer patients – a prospective observational study</atitle><jtitle>Journal of cancer survivorship</jtitle><stitle>J Cancer Surviv</stitle><addtitle>J Cancer Surviv</addtitle><date>2014-06-01</date><risdate>2014</risdate><volume>8</volume><issue>2</issue><spage>319</spage><epage>328</epage><pages>319-328</pages><issn>1932-2259</issn><eissn>1932-2267</eissn><abstract>Purpose
Cancer-related fatigue (CRF) has a major impact on the quality of life in breast cancer patients (BC). So far, only a few prospective studies have investigated the effect of adaptive salutogenic mechanisms on CRF. The aim of our study was to evaluate the possible prospective influence of autonomic Regulation (aR) and self-regulation (SR) on CRF and distress in long-term survivors.
Methods
95 BC and 80 healthy female controls (C) had been included in the observational study between 2000 and 2001 and completed the questionnaires on aR, SR and Hospital Anxiety and Depression Scale (HADS). Of these, 62 BC, and 58 C participated in the re-evaluation 6.6 years later: 16 participants were deceased (14 BC and 2 C). During follow-up, participants were requested to answer questions involving (Cancer Fatigue Scales) CFS-D, aR, SR and HADS. Multiple regression analysis was used to evaluate the influence of aR, SR, age, Charlson co-morbidity-index and diagnosis on CFS-D and HADS, and to select further potentially relevant factors.
Results
High aR values showed significant effects, namely inverse relationships with CFS-D, cognitive fatigue, anxiety and depression. SR showed a reduced influence on anxiety and depression (all p < 0.05).
Conclusions
Autonomic regulation might have an independent, reductive influence on global fatigue, cognitive fatigue and – together with self-regulation – it seems to have a protective influence on anxiety and depression. The connection between these parameters is still unclear and awaits further evaluation.
Implication for Cancer Survivors
AR seems to be a prognostic factor in breast cancer survivors, capable of reducing cancer-related fatigue and self-regulation distress as well. Further research is necessary in order to show how aR can be improved by therapeutic interventions.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>24253954</pmid><doi>10.1007/s11764-013-0314-6</doi><tpages>10</tpages></addata></record> |
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| subjects | Adult Aged Anxiety - physiopathology Breast cancer Cognition & reasoning Depression - physiopathology Emotions Fatigue Fatigue - physiopathology Female Health Informatics Health Promotion and Disease Prevention Humans Medicine Medicine & Public Health Middle Aged Neoplasms - mortality Neoplasms - physiopathology Neoplasms - psychology Oncology Primary Care Medicine Prospective Studies Public Health Quality of Life Quality of Life Research Surveys and Questionnaires Survivor Survivors |
| title | Impact of autonomic and self-regulation on cancer-related fatigue and distress in breast cancer patients – a prospective observational study |
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