Resistance to Arsenic Therapy in Acute Promyelocytic Leukemia

Although resistance to arsenic trioxide in patients with acute promyelocytic leukemia is very rare, mutations in PML at the site of arsenic binding appears to be the main mechanism of resistance. To the Editor: Acute promyelocytic leukemia (APL) is a highly curable disease. Recently, two randomized...

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Veröffentlicht in:	The New England journal of medicine 2014-05, Vol.370 (19), p.1864-1866
Hauptverfasser:	Zhu, Hong-Hu, Qin, Ya-Zhen, Huang, Xiao-Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute promyeloid leukemia Arsenic Arsenic trioxide Arsenicals - therapeutic use Chemotherapy Drug Resistance, Neoplasm - genetics Humans Leukemia Leukemia, Promyelocytic, Acute - drug therapy Leukemia, Promyelocytic, Acute - genetics Mutation Neoplasm Proteins - genetics Oxides - therapeutic use Promyeloid leukemia Receptors, Retinoic Acid - genetics Retinoic Acid Receptor alpha
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