Siderophore Receptor-Mediated Uptake of Lactivicin Analogues in Gram-Negative Bacteria

Multidrug-resistant Gram-negative pathogens are an emerging threat to human health, and addressing this challenge will require development of new antibacterial agents. This can be achieved through an improved molecular understanding of drug–target interactions combined with enhanced delivery of thes...

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Veröffentlicht in:	Journal of medicinal chemistry 2014-05, Vol.57 (9), p.3845-3855
Hauptverfasser:	Starr, Jeremy, Brown, Matthew F, Aschenbrenner, Lisa, Caspers, Nicole, Che, Ye, Gerstenberger, Brian S, Huband, Michael, Knafels, John D, Lemmon, M. Megan, Li, Chao, McCurdy, Sandra P, McElroy, Eric, Rauckhorst, Mark R, Tomaras, Andrew P, Young, Jennifer A, Zaniewski, Richard P, Shanmugasundaram, Veerabahu, Han, Seungil
Format:	Artikel
Sprache:	eng
Schlagworte:	beta-Lactamases - metabolism Gram-Negative Bacteria - drug effects Gram-Negative Bacteria - enzymology Gram-Negative Bacteria - metabolism Microbial Sensitivity Tests Peptides - drug effects Peptides - metabolism Receptors, Cell Surface - metabolism Siderophores - metabolism
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