Gout
SUMMARY POINTS Gout is associated with serious comorbidity and increased risk of cardiovascular disease The definitive diagnosis of gout requires microscopic identification of monosodium urate crystals A clinical diagnosis can be made when typical features of inflammation affect the first metatarsop...
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| Veröffentlicht in: | BMJ (Online) 2013-10, Vol.347 (7927), p.27-31 |
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| creator | Roddy, Edward Mallen, Christian D Doherty, Michael |
| description | SUMMARY POINTS Gout is associated with serious comorbidity and increased risk of cardiovascular disease The definitive diagnosis of gout requires microscopic identification of monosodium urate crystals A clinical diagnosis can be made when typical features of inflammation affect the first metatarsophalangeal joint; serum urate values have limited diagnostic value First line medical treatment options for acute gout are a non-steroidal anti-inflammatory drug or low dose colchicine Long term management requires full patient education, dealing with any modifiable risk factors (such as overweight or obesity, chronic diuretic intake), and urate lowering drugs Start altopurinol at a low dose (such as 100 mg daily) and increase gradually with the aim of lowering then maintaining serum urate below 360 µmol/L |
| doi_str_mv | 10.1136/bmj.f5648 |
| format | Article |
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therapeutic use ; Anti-Inflammatory Agents, Non-Steroidal - therapeutic use ; Arthritis ; Cardiovascular Diseases - diagnosis ; Cardiovascular Diseases - physiopathology ; CLINICAL REVIEW ; Colchicine - therapeutic use ; Comorbidity ; Confidence intervals ; Crystals ; Dosage ; Drug dosages ; Excretion ; Gout ; Gout - diagnosis ; Gout - drug therapy ; Gout - metabolism ; Gout - pathology ; Gout - physiopathology ; Gout Suppressants - therapeutic use ; Humans ; Hypertension ; Joints ; Male ; Metabolic syndrome ; Middle Aged ; Obesity ; Pain ; Patient Education as Topic ; Rheumatism ; Rheumatology ; Risk Reduction Behavior ; Soft drinks ; Swelling ; Toe Joint - drug effects ; Toe Joint - metabolism ; Toe Joint - pathology ; Toe Joint - physiopathology ; Uric acid ; Uric Acid - metabolism ; Weight control</subject><ispartof>BMJ (Online), 2013-10, Vol.347 (7927), p.27-31</ispartof><rights>BMJ Publishing Group Ltd 2013</rights><rights>Copyright: 2013 © BMJ Publishing Group Ltd 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b435t-a8f849652d4b92ac8371d04af6c43ea8a1e15f25e6295aac60e0d9131bbde8903</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttp://bmj.com/content/347/bmj.f5648.full.pdf$$EPDF$$P50$$Gbmj$$H</linktopdf><linktohtml>$$Uhttp://bmj.com/content/347/bmj.f5648.full$$EHTML$$P50$$Gbmj$$H</linktohtml><link.rule.ids>114,115,314,776,780,799,3183,23550,27901,27902,57992,58225,77342,77373</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24473446$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Roddy, Edward</creatorcontrib><creatorcontrib>Mallen, Christian D</creatorcontrib><creatorcontrib>Doherty, Michael</creatorcontrib><title>Gout</title><title>BMJ (Online)</title><addtitle>BMJ</addtitle><description>SUMMARY POINTS Gout is associated with serious comorbidity and increased risk of cardiovascular disease The definitive diagnosis of gout requires microscopic identification of monosodium urate crystals A clinical diagnosis can be made when typical features of inflammation affect the first metatarsophalangeal joint; serum urate values have limited diagnostic value First line medical treatment options for acute gout are a non-steroidal anti-inflammatory drug or low dose colchicine Long term management requires full patient education, dealing with any modifiable risk factors (such as overweight or obesity, chronic diuretic intake), and urate lowering drugs Start altopurinol at a low dose (such as 100 mg daily) and increase gradually with the aim of lowering then maintaining serum urate below 360 µmol/L</description><subject>Alcohol</subject><subject>Alcohol drinking</subject><subject>Allopurinol - therapeutic use</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - therapeutic use</subject><subject>Arthritis</subject><subject>Cardiovascular Diseases - diagnosis</subject><subject>Cardiovascular Diseases - physiopathology</subject><subject>CLINICAL REVIEW</subject><subject>Colchicine - therapeutic use</subject><subject>Comorbidity</subject><subject>Confidence intervals</subject><subject>Crystals</subject><subject>Dosage</subject><subject>Drug dosages</subject><subject>Excretion</subject><subject>Gout</subject><subject>Gout - diagnosis</subject><subject>Gout - drug therapy</subject><subject>Gout - metabolism</subject><subject>Gout - pathology</subject><subject>Gout - physiopathology</subject><subject>Gout Suppressants - therapeutic use</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Joints</subject><subject>Male</subject><subject>Metabolic syndrome</subject><subject>Middle Aged</subject><subject>Obesity</subject><subject>Pain</subject><subject>Patient Education as Topic</subject><subject>Rheumatism</subject><subject>Rheumatology</subject><subject>Risk Reduction Behavior</subject><subject>Soft drinks</subject><subject>Swelling</subject><subject>Toe Joint - drug effects</subject><subject>Toe Joint - metabolism</subject><subject>Toe Joint - pathology</subject><subject>Toe Joint - physiopathology</subject><subject>Uric acid</subject><subject>Uric Acid - metabolism</subject><subject>Weight control</subject><issn>0959-8138</issn><issn>1756-1833</issn><issn>1756-1833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqF0LFOwzAUBVALFdGqdOADYIEBhhQ_P9uxR6iggAoshdVyEkdqaJoSJxL8PS4pHZAQk4d7dPV8CTkCOgZAeZmUxTgXkqs9MoBYyAgUYo8MqBY6UoCqT0beF5RShrHSUhyQPuM8Rs7lgPSmVdsckv3cLr0bbd8hebm9mU_uotnz9H5yNYsSjqKJrMoVDwUs44lmNlUYQ0a5zWXK0VllwYHImXCSaWFtKqmjmQaEJMmc0hSH5LzrXdfVe-t8Y8qFT91yaVeuar0BwRC1Rqr_p1yzmDKGG3r6ixZVW6_CRwxoLpRimqugLjqV1pX3tcvNul6Utv40QM1mSBOGNN9DBnuybWyT0mU7-TNbAMcdKHxT1bs8rASMKx7yqMsXvnEfu9zWb0bGGAvz9Dox17OHOZ0_KgPBn3V-c8Pfd30B84eNzw</recordid><startdate>20131001</startdate><enddate>20131001</enddate><creator>Roddy, Edward</creator><creator>Mallen, Christian D</creator><creator>Doherty, Michael</creator><general>British Medical Journal Publishing Group</general><general>BMJ Publishing Group</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88I</scope><scope>8AF</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ASE</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FPQ</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K6X</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20131001</creationdate><title>Gout</title><author>Roddy, Edward ; Mallen, Christian D ; Doherty, Michael</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b435t-a8f849652d4b92ac8371d04af6c43ea8a1e15f25e6295aac60e0d9131bbde8903</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Alcohol</topic><topic>Alcohol drinking</topic><topic>Allopurinol - therapeutic use</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - therapeutic use</topic><topic>Arthritis</topic><topic>Cardiovascular Diseases - diagnosis</topic><topic>Cardiovascular Diseases - physiopathology</topic><topic>CLINICAL REVIEW</topic><topic>Colchicine - therapeutic use</topic><topic>Comorbidity</topic><topic>Confidence intervals</topic><topic>Crystals</topic><topic>Dosage</topic><topic>Drug dosages</topic><topic>Excretion</topic><topic>Gout</topic><topic>Gout - diagnosis</topic><topic>Gout - drug therapy</topic><topic>Gout - metabolism</topic><topic>Gout - pathology</topic><topic>Gout - physiopathology</topic><topic>Gout Suppressants - therapeutic use</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Joints</topic><topic>Male</topic><topic>Metabolic syndrome</topic><topic>Middle Aged</topic><topic>Obesity</topic><topic>Pain</topic><topic>Patient Education as Topic</topic><topic>Rheumatism</topic><topic>Rheumatology</topic><topic>Risk Reduction Behavior</topic><topic>Soft drinks</topic><topic>Swelling</topic><topic>Toe Joint - drug effects</topic><topic>Toe Joint - metabolism</topic><topic>Toe Joint - pathology</topic><topic>Toe Joint - physiopathology</topic><topic>Uric acid</topic><topic>Uric Acid - metabolism</topic><topic>Weight control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Roddy, Edward</creatorcontrib><creatorcontrib>Mallen, Christian D</creatorcontrib><creatorcontrib>Doherty, Michael</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Index</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>British Nursing Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>BMJ (Online)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Roddy, Edward</au><au>Mallen, Christian D</au><au>Doherty, Michael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gout</atitle><jtitle>BMJ (Online)</jtitle><addtitle>BMJ</addtitle><date>2013-10-01</date><risdate>2013</risdate><volume>347</volume><issue>7927</issue><spage>27</spage><epage>31</epage><pages>27-31</pages><issn>0959-8138</issn><issn>1756-1833</issn><eissn>1756-1833</eissn><abstract>SUMMARY POINTS Gout is associated with serious comorbidity and increased risk of cardiovascular disease The definitive diagnosis of gout requires microscopic identification of monosodium urate crystals A clinical diagnosis can be made when typical features of inflammation affect the first metatarsophalangeal joint; serum urate values have limited diagnostic value First line medical treatment options for acute gout are a non-steroidal anti-inflammatory drug or low dose colchicine Long term management requires full patient education, dealing with any modifiable risk factors (such as overweight or obesity, chronic diuretic intake), and urate lowering drugs Start altopurinol at a low dose (such as 100 mg daily) and increase gradually with the aim of lowering then maintaining serum urate below 360 µmol/L</abstract><cop>England</cop><pub>British Medical Journal Publishing Group</pub><pmid>24473446</pmid><doi>10.1136/bmj.f5648</doi><tpages>5</tpages></addata></record> |
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| ispartof | BMJ (Online), 2013-10, Vol.347 (7927), p.27-31 |
| issn | 0959-8138 1756-1833 1756-1833 |
| language | eng |
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| source | Jstor Complete Legacy; MEDLINE; BMJ Journals - NESLi2 |
| subjects | Alcohol Alcohol drinking Allopurinol - therapeutic use Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Arthritis Cardiovascular Diseases - diagnosis Cardiovascular Diseases - physiopathology CLINICAL REVIEW Colchicine - therapeutic use Comorbidity Confidence intervals Crystals Dosage Drug dosages Excretion Gout Gout - diagnosis Gout - drug therapy Gout - metabolism Gout - pathology Gout - physiopathology Gout Suppressants - therapeutic use Humans Hypertension Joints Male Metabolic syndrome Middle Aged Obesity Pain Patient Education as Topic Rheumatism Rheumatology Risk Reduction Behavior Soft drinks Swelling Toe Joint - drug effects Toe Joint - metabolism Toe Joint - pathology Toe Joint - physiopathology Uric acid Uric Acid - metabolism Weight control |
| title | Gout |
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