Elevated plasma corticosterone levels and histopathology of the adrenals and thymuses in 2,3,7,8-tetrachlorodibenzo- p-dioxin-treated rats

The relationship between thymic atrophy and plasma corticosterone levels was examined in 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD)-treated, pair-fed and ad libitum-fed male Sprague - Dawley rats given a usually lethal (125 μg/kg) or non-lethal (25 μg/kg dose of TCDD. At both dosages, corticosteron...

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Veröffentlicht in:	Toxicology (Amsterdam) 1988-12, Vol.53 (1), p.19-32
Hauptverfasser:	Gorski, Joel R., Muzi, Giacomo, Weber, Lutz W., Pereira, David W., Iatropoulos, Michael J., Rozman, Karl
Format:	Artikel
Sprache:	eng
Schlagworte:	2,3,7,8-Tetrachlorodibenzo- p-dioxin(TCDD) Adrenal changes Adrenal Glands - drug effects Adrenal Glands - pathology Animals Biological and medical sciences Body Weight - drug effects Chemical and industrial products toxicology. Toxic occupational diseases Corticosterone Corticosterone - blood Dioxins - toxicity Dose-Response Relationship, Drug Eating Male Medical sciences Organ Size - drug effects Polychlorinated Dibenzodioxins - toxicity Rats Rats, Inbred Strains Thymmic atrophy Thymus Gland - drug effects Thymus Gland - pathology Toxicology Various organic compounds
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