Isolated light chains of botulinum neurotoxins inhibit exocytosis. Studies in digitonin-permeabilized chromaffin cells

The effects of botulinum neurotoxins or their light and heavy chain subunits were investigated in digitonin-permeabilized adrenal chromaffin cells. Because these cells are permeable to proteins, the toxin had direct access to the cell interior. Botulinum type A neurotoxin and its light chain subunit...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of biological chemistry 1989-06, Vol.264 (18), p.10354-10360
Hauptverfasser:	BITTNER, M. A, DASGUPTA, B. R, HOLZ, R. W
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal Medulla - drug effects Adrenal Medulla - metabolism Animals Bacteriology Biological and medical sciences Botulinum Toxins - isolation & purification Botulinum Toxins - pharmacology Cattle Cell Membrane Permeability Cells, Cultured chromaffin cells Clostridium botulinum Digitonin exocytosis Exocytosis - drug effects Fundamental and applied biological sciences. Psychology Kinetics Macromolecular Substances Microbiology Neurotoxins Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains Trypsin
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!