Analysis of SecA2‐dependent substrates in Mycobacterium marinum identifies protein kinase G (PknG) as a virulence effector

Summary The pathogenicity of mycobacteria is closely associated with their ability to export virulence factors. For this purpose, mycobacteria possess different protein secretion systems, including the accessory Sec translocation pathway, SecA2. Although this pathway is associated with intracellular...

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Veröffentlicht in:	Cellular microbiology 2014-02, Vol.16 (2), p.280-295
Hauptverfasser:	Woude, Aniek D., Stoop, Esther J. M., Stiess, Michael, Wang, Sen, Ummels, Roy, Stempvoort, Gunny, Piersma, Sander R., Cascioferro, Alessandro, Jiménez, Connie R., Houben, Edith N. G., Luirink, Joen, Pieters, Jean, Sar, Astrid M., Bitter, Wilbert
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphatases - metabolism Animals Bacterial Proteins - metabolism Bacteriology Cyclic GMP-Dependent Protein Kinases - metabolism Danio rerio Disease Models, Animal DNA Transposable Elements Gene Knockout Techniques Immunoblotting Kinases Membrane Transport Proteins - metabolism Mutagenesis, Insertional Mycobacterium Mycobacterium Infections - microbiology Mycobacterium marinum Mycobacterium marinum - metabolism Mycobacterium marinum - pathogenicity Proteins Substrate Specificity Virulence Factors - metabolism Zebrafish
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