Bronchoscopic finding determined outcome after chemoradiotherapy in esophageal cancer patients with airway invasion
Background We studied whether the bronchoscopic findings could be help to predict outcome after chemoradiotherapy (CRT) in patients with airway invasion by esophageal cancer. Method Between 2000 and 2010, we retrospectively investigated esophageal cancer patients with T4 disease due to airway invasi...
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| Veröffentlicht in: | Journal of surgical oncology 2014-06, Vol.109 (8), p.808-811 |
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| container_title | Journal of surgical oncology |
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| creator | Yin, Shun-Ying Chao, Yin-Kai Tseng, Chen-Kan Chang, Hsien-Kun Liu, Yun-Hen Wu, Yi-Cheng Chen, Tzu-Ping Yeh, Chi-Hsiao |
| description | Background
We studied whether the bronchoscopic findings could be help to predict outcome after chemoradiotherapy (CRT) in patients with airway invasion by esophageal cancer.
Method
Between 2000 and 2010, we retrospectively investigated esophageal cancer patients with T4 disease due to airway invasion who had received CRT as first line treatment. Airway invasion is defined as infiltration of the tracheobronchial wall or protruded intraluminal growth on bronchoscopy. The total radiation dose of CRT was 60 Gy and divided into two cycles. Bronchoscopic findings were evaluated together with other clinical parameters and correlated with overall survival (OS).
Result
There were 68 patients with a mean age of 54.5 years. After the first cycle of CRT, bronchoscopic examination showed complete regression of endobronchial lesion in 16 patients. OS was 26% at 1 year and 5% at 3 years with the median survival time (MST) of 7 months. Multivariate analysis revealed vocal cord palsy (unfavorable, OR [95% CI]:2 [1.07–3.84], P = 0.03), carina involvement (unfavorable, OR [95% CI]:2.6 [1.12–6], P = 0.025) and intraluminal tumor growth (unfavorable, OR [95% CI]:1.9 [1.1–3.3], P = 0.023) as independent factors for survival. The MST after CRT was 12.1, 6.1, 5.7 months in patients with 0, 1, 2 factors, respectively (P |
| doi_str_mv | 10.1002/jso.23578 |
| format | Article |
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We studied whether the bronchoscopic findings could be help to predict outcome after chemoradiotherapy (CRT) in patients with airway invasion by esophageal cancer.
Method
Between 2000 and 2010, we retrospectively investigated esophageal cancer patients with T4 disease due to airway invasion who had received CRT as first line treatment. Airway invasion is defined as infiltration of the tracheobronchial wall or protruded intraluminal growth on bronchoscopy. The total radiation dose of CRT was 60 Gy and divided into two cycles. Bronchoscopic findings were evaluated together with other clinical parameters and correlated with overall survival (OS).
Result
There were 68 patients with a mean age of 54.5 years. After the first cycle of CRT, bronchoscopic examination showed complete regression of endobronchial lesion in 16 patients. OS was 26% at 1 year and 5% at 3 years with the median survival time (MST) of 7 months. Multivariate analysis revealed vocal cord palsy (unfavorable, OR [95% CI]:2 [1.07–3.84], P = 0.03), carina involvement (unfavorable, OR [95% CI]:2.6 [1.12–6], P = 0.025) and intraluminal tumor growth (unfavorable, OR [95% CI]:1.9 [1.1–3.3], P = 0.023) as independent factors for survival. The MST after CRT was 12.1, 6.1, 5.7 months in patients with 0, 1, 2 factors, respectively (P < 0.001).
Conclusion
Bronchoscopic finding determined outcome after CRT in esophageal cancer patients with airway invasion J. Surg. Oncol. 2014 109:808–811. © 2014 Wiley Periodicals, Inc.</description><identifier>ISSN: 0022-4790</identifier><identifier>EISSN: 1096-9098</identifier><identifier>DOI: 10.1002/jso.23578</identifier><identifier>PMID: 24578225</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>airway invasion ; Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; Bronchoscopy ; Chemoradiotherapy ; Cisplatin - administration & dosage ; esophageal cancer ; Esophageal Neoplasms - mortality ; Esophageal Neoplasms - pathology ; Esophageal Neoplasms - therapy ; Female ; Fluorouracil - administration & dosage ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Neoplasm Invasiveness ; Neoplasm Staging ; Prognosis ; prognostic factor ; Respiratory System - pathology ; Retrospective Studies ; Survival Rate</subject><ispartof>Journal of surgical oncology, 2014-06, Vol.109 (8), p.808-811</ispartof><rights>2014 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3918-5fff90d6481ab9fc5a299f6f917bbac69bffc0fd45c45d520ee3a3c96eb117263</citedby><cites>FETCH-LOGICAL-c3918-5fff90d6481ab9fc5a299f6f917bbac69bffc0fd45c45d520ee3a3c96eb117263</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjso.23578$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjso.23578$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24578225$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yin, Shun-Ying</creatorcontrib><creatorcontrib>Chao, Yin-Kai</creatorcontrib><creatorcontrib>Tseng, Chen-Kan</creatorcontrib><creatorcontrib>Chang, Hsien-Kun</creatorcontrib><creatorcontrib>Liu, Yun-Hen</creatorcontrib><creatorcontrib>Wu, Yi-Cheng</creatorcontrib><creatorcontrib>Chen, Tzu-Ping</creatorcontrib><creatorcontrib>Yeh, Chi-Hsiao</creatorcontrib><title>Bronchoscopic finding determined outcome after chemoradiotherapy in esophageal cancer patients with airway invasion</title><title>Journal of surgical oncology</title><addtitle>J. Surg. Oncol</addtitle><description>Background
We studied whether the bronchoscopic findings could be help to predict outcome after chemoradiotherapy (CRT) in patients with airway invasion by esophageal cancer.
Method
Between 2000 and 2010, we retrospectively investigated esophageal cancer patients with T4 disease due to airway invasion who had received CRT as first line treatment. Airway invasion is defined as infiltration of the tracheobronchial wall or protruded intraluminal growth on bronchoscopy. The total radiation dose of CRT was 60 Gy and divided into two cycles. Bronchoscopic findings were evaluated together with other clinical parameters and correlated with overall survival (OS).
Result
There were 68 patients with a mean age of 54.5 years. After the first cycle of CRT, bronchoscopic examination showed complete regression of endobronchial lesion in 16 patients. OS was 26% at 1 year and 5% at 3 years with the median survival time (MST) of 7 months. Multivariate analysis revealed vocal cord palsy (unfavorable, OR [95% CI]:2 [1.07–3.84], P = 0.03), carina involvement (unfavorable, OR [95% CI]:2.6 [1.12–6], P = 0.025) and intraluminal tumor growth (unfavorable, OR [95% CI]:1.9 [1.1–3.3], P = 0.023) as independent factors for survival. The MST after CRT was 12.1, 6.1, 5.7 months in patients with 0, 1, 2 factors, respectively (P < 0.001).
Conclusion
Bronchoscopic finding determined outcome after CRT in esophageal cancer patients with airway invasion J. Surg. Oncol. 2014 109:808–811. © 2014 Wiley Periodicals, Inc.</description><subject>airway invasion</subject><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</subject><subject>Bronchoscopy</subject><subject>Chemoradiotherapy</subject><subject>Cisplatin - administration & dosage</subject><subject>esophageal cancer</subject><subject>Esophageal Neoplasms - mortality</subject><subject>Esophageal Neoplasms - pathology</subject><subject>Esophageal Neoplasms - therapy</subject><subject>Female</subject><subject>Fluorouracil - administration & dosage</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neoplasm Invasiveness</subject><subject>Neoplasm Staging</subject><subject>Prognosis</subject><subject>prognostic factor</subject><subject>Respiratory System - pathology</subject><subject>Retrospective Studies</subject><subject>Survival Rate</subject><issn>0022-4790</issn><issn>1096-9098</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10c1u1DAUBWALgehQWPACyBIbWKS1ndiJl7Si5WdEkVrE0nKc68ZDYqd20mHeHpdpu0BiZcn-7pF1D0KvKTmihLDjTQpHrOR18wStKJGikEQ2T9Eqv7GiqiU5QC9S2hBCpBTVc3TAqowZ4yuUTmLwpg_JhMkZbJ3vnL_GHcwQR-ehw2GZTRgBa5uvsOlhDFF3Lsw9RD3tsPMYUph6fQ16wEZ7k9mkZwd-Tnjr5h5rF7f6Tt7q5IJ_iZ5ZPSR4dX8eoh9nH69OPxXri_PPpx_WhSklbQpurZWkE1VDdSut4ZpJaYWVtG5bbYRsrTXEdhU3Fe84IwClLo0U0FJaM1Eeonf73CmGmwXSrEaXDAyD9hCWpChnTDSk5jLTt__QTViiz7_LildS0JqwrN7vlYkhpQhWTdGNOu4UJequCZWbUH-byPbNfeLSjtA9yofVZ3C8B1s3wO7_SerL5cVDZLGfcGmG348TOv5Soi5rrn5-O1dfv5-s6ytSqsvyDxXzpIk</recordid><startdate>20140601</startdate><enddate>20140601</enddate><creator>Yin, Shun-Ying</creator><creator>Chao, Yin-Kai</creator><creator>Tseng, Chen-Kan</creator><creator>Chang, Hsien-Kun</creator><creator>Liu, Yun-Hen</creator><creator>Wu, Yi-Cheng</creator><creator>Chen, Tzu-Ping</creator><creator>Yeh, Chi-Hsiao</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20140601</creationdate><title>Bronchoscopic finding determined outcome after chemoradiotherapy in esophageal cancer patients with airway invasion</title><author>Yin, Shun-Ying ; Chao, Yin-Kai ; Tseng, Chen-Kan ; Chang, Hsien-Kun ; Liu, Yun-Hen ; Wu, Yi-Cheng ; Chen, Tzu-Ping ; Yeh, Chi-Hsiao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3918-5fff90d6481ab9fc5a299f6f917bbac69bffc0fd45c45d520ee3a3c96eb117263</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>airway invasion</topic><topic>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</topic><topic>Bronchoscopy</topic><topic>Chemoradiotherapy</topic><topic>Cisplatin - administration & dosage</topic><topic>esophageal cancer</topic><topic>Esophageal Neoplasms - mortality</topic><topic>Esophageal Neoplasms - pathology</topic><topic>Esophageal Neoplasms - therapy</topic><topic>Female</topic><topic>Fluorouracil - administration & dosage</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neoplasm Invasiveness</topic><topic>Neoplasm Staging</topic><topic>Prognosis</topic><topic>prognostic factor</topic><topic>Respiratory System - pathology</topic><topic>Retrospective Studies</topic><topic>Survival Rate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yin, Shun-Ying</creatorcontrib><creatorcontrib>Chao, Yin-Kai</creatorcontrib><creatorcontrib>Tseng, Chen-Kan</creatorcontrib><creatorcontrib>Chang, Hsien-Kun</creatorcontrib><creatorcontrib>Liu, Yun-Hen</creatorcontrib><creatorcontrib>Wu, Yi-Cheng</creatorcontrib><creatorcontrib>Chen, Tzu-Ping</creatorcontrib><creatorcontrib>Yeh, Chi-Hsiao</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yin, Shun-Ying</au><au>Chao, Yin-Kai</au><au>Tseng, Chen-Kan</au><au>Chang, Hsien-Kun</au><au>Liu, Yun-Hen</au><au>Wu, Yi-Cheng</au><au>Chen, Tzu-Ping</au><au>Yeh, Chi-Hsiao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bronchoscopic finding determined outcome after chemoradiotherapy in esophageal cancer patients with airway invasion</atitle><jtitle>Journal of surgical oncology</jtitle><addtitle>J. Surg. Oncol</addtitle><date>2014-06-01</date><risdate>2014</risdate><volume>109</volume><issue>8</issue><spage>808</spage><epage>811</epage><pages>808-811</pages><issn>0022-4790</issn><eissn>1096-9098</eissn><abstract>Background
We studied whether the bronchoscopic findings could be help to predict outcome after chemoradiotherapy (CRT) in patients with airway invasion by esophageal cancer.
Method
Between 2000 and 2010, we retrospectively investigated esophageal cancer patients with T4 disease due to airway invasion who had received CRT as first line treatment. Airway invasion is defined as infiltration of the tracheobronchial wall or protruded intraluminal growth on bronchoscopy. The total radiation dose of CRT was 60 Gy and divided into two cycles. Bronchoscopic findings were evaluated together with other clinical parameters and correlated with overall survival (OS).
Result
There were 68 patients with a mean age of 54.5 years. After the first cycle of CRT, bronchoscopic examination showed complete regression of endobronchial lesion in 16 patients. OS was 26% at 1 year and 5% at 3 years with the median survival time (MST) of 7 months. Multivariate analysis revealed vocal cord palsy (unfavorable, OR [95% CI]:2 [1.07–3.84], P = 0.03), carina involvement (unfavorable, OR [95% CI]:2.6 [1.12–6], P = 0.025) and intraluminal tumor growth (unfavorable, OR [95% CI]:1.9 [1.1–3.3], P = 0.023) as independent factors for survival. The MST after CRT was 12.1, 6.1, 5.7 months in patients with 0, 1, 2 factors, respectively (P < 0.001).
Conclusion
Bronchoscopic finding determined outcome after CRT in esophageal cancer patients with airway invasion J. Surg. Oncol. 2014 109:808–811. © 2014 Wiley Periodicals, Inc.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>24578225</pmid><doi>10.1002/jso.23578</doi><tpages>4</tpages></addata></record> |
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| source | MEDLINE; Wiley Journals |
| subjects | airway invasion Antineoplastic Combined Chemotherapy Protocols - therapeutic use Bronchoscopy Chemoradiotherapy Cisplatin - administration & dosage esophageal cancer Esophageal Neoplasms - mortality Esophageal Neoplasms - pathology Esophageal Neoplasms - therapy Female Fluorouracil - administration & dosage Follow-Up Studies Humans Male Middle Aged Neoplasm Invasiveness Neoplasm Staging Prognosis prognostic factor Respiratory System - pathology Retrospective Studies Survival Rate |
| title | Bronchoscopic finding determined outcome after chemoradiotherapy in esophageal cancer patients with airway invasion |
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