Characteristics of individuals with breast cancer rearrangements in BRCA1 and BRCA2

BACKGROUND Large rearrangements in BRCA1 and BRCA2 occur in a small percentage (< 1%) of patients tested for hereditary breast (BC) and ovarian cancer. It is unclear what factors predict BRACAnalysis Large Rearrangement Test (BART) positivity. METHODS Data from 6 centers were included in this ana...

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Veröffentlicht in:	Cancer 2014-05, Vol.120 (10), p.1557-1564
Hauptverfasser:	Jackson, Sarah A., Davis, Andrew A., Li, Jun, Yi, Nengjun, McCormick, Shelley R., Grant, Carly, Fallen, Taya, Crawford, Beth, Loranger, Kate, Litton, Jennifer, Arun, Banu, Vande Wydeven, Kimberly, Sidani, Amer, Farmer, Katie, Sanders, Merideth, Hoskins, Kent, Nussbaum, Robert, Esserman, Laura, Garber, Judy E., Kaklamani, Virginia G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma, Mucinous - genetics Adult African Americans - genetics African Americans - statistics & numerical data Aged Aged, 80 and over Area Under Curve BART Biological and medical sciences Biomarkers, Tumor - analysis BRCA1 BRCA1 Protein - genetics BRCA2 BRCA2 Protein - genetics breast cancer breast cancer rearrangement mutations Breast Neoplasms - ethnology Breast Neoplasms - genetics Breast Neoplasms - pathology Carcinoma, Ductal, Breast - genetics Carcinoma, Intraductal, Noninfiltrating - genetics Carcinoma, Lobular - genetics Caribbean Region - ethnology Carrier Proteins - genetics Europe - ethnology European Continental Ancestry Group - genetics European Continental Ancestry Group - statistics & numerical data Exons - genetics Female Gene Deletion Gene Duplication Genes, BRCA1 Genes, BRCA2 Genetic Predisposition to Disease Gynecology. Andrology. Obstetrics Hispanic Americans - genetics Hispanic Americans - statistics & numerical data Humans Jews - genetics Jews - statistics & numerical data Mammary gland diseases Medical sciences Middle Aged Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Mutation mutations Ovarian Neoplasms - ethnology Ovarian Neoplasms - genetics Predictive Value of Tests Risk Tumors United States
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