60 Hz Electric Field Changes the Membrane Potential During Burst Phase in Pancreatic β-Cells: In Silico Analysis
The production, distribution and use of electricity can generate low frequency electric and magnetic fields (50–60 Hz). Considering that some studies showed adverse effects on pancreatic β-cells exposed to these fields; the present study aimed to analyze the effects of 60 Hz electric fields on membr...
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| Veröffentlicht in: | Acta biotheoretica 2014-06, Vol.62 (2), p.133-143 |
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| container_title | Acta biotheoretica |
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| creator | Neves, Gesilda F. Silva, José R. F. Moraes, Renato B. Fernandes, Thiago S. Tenorio, Bruno M. Nogueira, Romildo A. |
| description | The production, distribution and use of electricity can generate low frequency electric and magnetic fields (50–60 Hz). Considering that some studies showed adverse effects on pancreatic β-cells exposed to these fields; the present study aimed to analyze the effects of 60 Hz electric fields on membrane potential during the silent and burst phases in pancreatic β-cells using a mathematical model. Sinusoidal 60 Hz electric fields with amplitude ranging from 0.5 to 4 mV were applied on pancreatic β-cells model. The sinusoidal electric field changed burst duration, inter-burst intervals (silent phase) and spike sizes. The parameters above presented dose-dependent response with the voltage amplitude applied. In conclusion, theoretical analyses showed that a 60 Hz electric field with low amplitudes changes the membrane potential in pancreatic β-cells. |
| doi_str_mv | 10.1007/s10441-014-9214-z |
| format | Article |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Action Potentials Computer Simulation Education Electricity Evolutionary Biology Islets of Langerhans - physiology Membrane Potentials Philosophy Philosophy of Biology Regular Article |
| title | 60 Hz Electric Field Changes the Membrane Potential During Burst Phase in Pancreatic β-Cells: In Silico Analysis |
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