The immune contexture of primary and metastatic human tumours

The immune contexture of primary and metastatic human tumours

Highlights • The immune contexture is a powerful tool to predict patient's clinical outcome. • Chronic inflammation can foster cancer development and tumour growth. • An adaptive immune response predicts longer survival in most cancers with some exceptions such as kidney cancer and Hodgkin lymp...

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Veröffentlicht in:Current opinion in immunology 2014-04, Vol.27, p.8-15
Hauptverfasser: Giraldo, Nicolas A, Becht, Etienne, Remark, Romain, Damotte, Diane, Sautès-Fridman, Catherine, Fridman, Wolf H
Format: Artikel
Sprache:eng
Schlagworte:
Allergy and Immunology
Humans
Inflammation - immunology
Lymphocytes, Tumor-Infiltrating - immunology
Neoplasm Metastasis
Neoplasms - immunology
Neoplasms - pathology
Tumor Microenvironment
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Zusammenfassung:Highlights • The immune contexture is a powerful tool to predict patient's clinical outcome. • Chronic inflammation can foster cancer development and tumour growth. • An adaptive immune response predicts longer survival in most cancers with some exceptions such as kidney cancer and Hodgkin lymphoma. • Immune contexture can be strongly influenced by tumour-originating factors. • Immune contexture is preserved during the metastatic process and conserves its prognostic value.
ISSN:0952-7915
1879-0372
DOI:10.1016/j.coi.2014.01.001