Studies on the intoxication pathway of tetanus toxin in the rat pheochromocytoma (PC12) cell line. Binding, internalization, and inhibition of acetylcholine release

Tetanus toxin was found to be a potent inhibitor of neurosecretion in the rat pheochromocytoma cell line PC12, a system in which biochemical and functional studies could be performed in parallel. Incubation of the cells with 10 nM tetanus toxin (3 h) led to an inhibition of acetylcholine release by...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of biological chemistry 1989-04, Vol.264 (10), p.5679-5686
Hauptverfasser:	SANDBERG, K, BERRY, C. J, ROGERS, T. B
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - metabolism Adrenal Gland Neoplasms Animals Biological and medical sciences Cell Line Cell physiology Choline - metabolism Clostridium tetani Fundamental and applied biological sciences. Psychology Kinetics Molecular and cellular biology Pheochromocytoma Rats Secretion. Exocytosis Tetanus Toxin - metabolism Tetanus Toxin - pharmacology Tumor Cells, Cultured - drug effects Tumor Cells, Cultured - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!