Anabolic androgenic steroids reverse the beneficial effect of exercise on tendon biomechanics: An experimental study
Abstract Background The effect of anabolic androgenic steroids on tendons has not yet been fully elucidated. Aim of the present study was the evaluation of the impact of anabolic androgenic steroids on the biomechanical and histological characteristics of Achilles tendons. Methods Twenty-four male W...
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| Veröffentlicht in: | Foot and ankle surgery 2014-06, Vol.20 (2), p.94-99 |
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| creator | Tsitsilonis, Serafim, MD, MSc, PhD Panayiotis, Chatzistergos E., PhD Athanasios, Mitousoudis S., PhD Stavros, Kourkoulis K., PhD Ioannis, Vlachos S., MSc George, Agrogiannis, MD Konstantinos, Fasseas, PhD Despina, Perrea N., PhD Aristides, Zoubos B., MD, PhD |
| description | Abstract Background The effect of anabolic androgenic steroids on tendons has not yet been fully elucidated. Aim of the present study was the evaluation of the impact of anabolic androgenic steroids on the biomechanical and histological characteristics of Achilles tendons. Methods Twenty-four male Wistar rats were randomized into four groups with exercise and anabolic steroids (nandrolone decanoate) serving as variables. Protocol duration was 12 weeks. Following euthanasia, tendons’ biomechanical properties were tested with the use of a modified clamping configuration. Histological examination with light and electron microscopy were also performed. Results In the group of anabolic steroids and exercise the lowest fracture stress values were observed, while in the exercise group the highest ones. Histological examination by light and electron microscopy revealed areas of collagen dysplasia and an increased epitendon in the groups receiving anabolic steroids and exercise. Conclusions These findings suggest that anabolic androgenic steroids reverse the beneficial effect of exercise, thus resulting in inferior maximal stress values. |
| doi_str_mv | 10.1016/j.fas.2013.12.001 |
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Aim of the present study was the evaluation of the impact of anabolic androgenic steroids on the biomechanical and histological characteristics of Achilles tendons. Methods Twenty-four male Wistar rats were randomized into four groups with exercise and anabolic steroids (nandrolone decanoate) serving as variables. Protocol duration was 12 weeks. Following euthanasia, tendons’ biomechanical properties were tested with the use of a modified clamping configuration. Histological examination with light and electron microscopy were also performed. Results In the group of anabolic steroids and exercise the lowest fracture stress values were observed, while in the exercise group the highest ones. Histological examination by light and electron microscopy revealed areas of collagen dysplasia and an increased epitendon in the groups receiving anabolic steroids and exercise. Conclusions These findings suggest that anabolic androgenic steroids reverse the beneficial effect of exercise, thus resulting in inferior maximal stress values.</description><identifier>ISSN: 1268-7731</identifier><identifier>EISSN: 1460-9584</identifier><identifier>DOI: 10.1016/j.fas.2013.12.001</identifier><identifier>PMID: 24796826</identifier><language>eng</language><publisher>France: Elsevier Ltd</publisher><subject>Achilles tendon ; Achilles Tendon - drug effects ; Achilles Tendon - physiology ; Anabolic Agents - pharmacology ; Anabolic androgenic steroids ; Animals ; Biomechanical Phenomena ; Biomechanics ; Collagen - drug effects ; Male ; Motor Activity - physiology ; Nandrolone - analogs & derivatives ; Nandrolone - pharmacology ; Orthopedics ; Rats ; Rats, Wistar ; Rupture</subject><ispartof>Foot and ankle surgery, 2014-06, Vol.20 (2), p.94-99</ispartof><rights>European Foot and Ankle Society</rights><rights>2013 European Foot and Ankle Society</rights><rights>Copyright © 2013 European Foot and Ankle Society. Published by Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c451t-62eaeeacd6777e7e6804c67b289f8a7ff9ef576af8c6397fe1bc2c5f9cee70ee3</citedby><cites>FETCH-LOGICAL-c451t-62eaeeacd6777e7e6804c67b289f8a7ff9ef576af8c6397fe1bc2c5f9cee70ee3</cites><orcidid>0000-0002-6529-6864</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1268773113001318$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24796826$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tsitsilonis, Serafim, MD, MSc, PhD</creatorcontrib><creatorcontrib>Panayiotis, Chatzistergos E., PhD</creatorcontrib><creatorcontrib>Athanasios, Mitousoudis S., PhD</creatorcontrib><creatorcontrib>Stavros, Kourkoulis K., PhD</creatorcontrib><creatorcontrib>Ioannis, Vlachos S., MSc</creatorcontrib><creatorcontrib>George, Agrogiannis, MD</creatorcontrib><creatorcontrib>Konstantinos, Fasseas, PhD</creatorcontrib><creatorcontrib>Despina, Perrea N., PhD</creatorcontrib><creatorcontrib>Aristides, Zoubos B., MD, PhD</creatorcontrib><title>Anabolic androgenic steroids reverse the beneficial effect of exercise on tendon biomechanics: An experimental study</title><title>Foot and ankle surgery</title><addtitle>Foot Ankle Surg</addtitle><description>Abstract Background The effect of anabolic androgenic steroids on tendons has not yet been fully elucidated. Aim of the present study was the evaluation of the impact of anabolic androgenic steroids on the biomechanical and histological characteristics of Achilles tendons. Methods Twenty-four male Wistar rats were randomized into four groups with exercise and anabolic steroids (nandrolone decanoate) serving as variables. Protocol duration was 12 weeks. Following euthanasia, tendons’ biomechanical properties were tested with the use of a modified clamping configuration. Histological examination with light and electron microscopy were also performed. Results In the group of anabolic steroids and exercise the lowest fracture stress values were observed, while in the exercise group the highest ones. Histological examination by light and electron microscopy revealed areas of collagen dysplasia and an increased epitendon in the groups receiving anabolic steroids and exercise. Conclusions These findings suggest that anabolic androgenic steroids reverse the beneficial effect of exercise, thus resulting in inferior maximal stress values.</description><subject>Achilles tendon</subject><subject>Achilles Tendon - drug effects</subject><subject>Achilles Tendon - physiology</subject><subject>Anabolic Agents - pharmacology</subject><subject>Anabolic androgenic steroids</subject><subject>Animals</subject><subject>Biomechanical Phenomena</subject><subject>Biomechanics</subject><subject>Collagen - drug effects</subject><subject>Male</subject><subject>Motor Activity - physiology</subject><subject>Nandrolone - analogs & derivatives</subject><subject>Nandrolone - pharmacology</subject><subject>Orthopedics</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Rupture</subject><issn>1268-7731</issn><issn>1460-9584</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kT2P1DAURSMEYpeFH0CDUtIk-DmJnYCENFrxJa1EAdSW41yzHjL2YCcr5t_jaBYKCqr3inuu7POK4jmxmhiJV_va6lRzRk1NvGaMHhSX1ApWDV3fPsw7F30lZUMXxZOU9owxObDmcXHBWzmInovLYtl5PYbZmVL7KYbv8HlNC2JwUyoj7hATyuUW5QgP64zTcwlrYZYy2BK_EI3LieDLBX7KY3ThAHOrc1F6Xe58zhwR3QF-yWha1un0tHhk9Zzw7H5eFd_ev_t6_bG6-fzh0_XupjJtR0slODSgzSSklJAQPWuNkCPvB9trae0A20mhbW9EM0gLGg03nR0MIBnQXBUvz73HGH6uSIs6uGQwz9ojrElRx2kg1rAmR-kcNTGkFGHVMb9Zx5MipjbZaq-ybLXJVsRVlp2ZF_f163jA9Jf4YzcH3pwDyJ-8c4gqGQdvMLmYBaopuP_Wv_2HNrPLVvX8AyekfVijz_YUqZQB9WW79nZsajaa-uY3SOmnVg</recordid><startdate>20140601</startdate><enddate>20140601</enddate><creator>Tsitsilonis, Serafim, MD, MSc, PhD</creator><creator>Panayiotis, Chatzistergos E., PhD</creator><creator>Athanasios, Mitousoudis S., PhD</creator><creator>Stavros, Kourkoulis K., PhD</creator><creator>Ioannis, Vlachos S., MSc</creator><creator>George, Agrogiannis, MD</creator><creator>Konstantinos, Fasseas, PhD</creator><creator>Despina, Perrea N., PhD</creator><creator>Aristides, Zoubos B., MD, PhD</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6529-6864</orcidid></search><sort><creationdate>20140601</creationdate><title>Anabolic androgenic steroids reverse the beneficial effect of exercise on tendon biomechanics: An experimental study</title><author>Tsitsilonis, Serafim, MD, MSc, PhD ; Panayiotis, Chatzistergos E., PhD ; Athanasios, Mitousoudis S., PhD ; Stavros, Kourkoulis K., PhD ; Ioannis, Vlachos S., MSc ; George, Agrogiannis, MD ; Konstantinos, Fasseas, PhD ; Despina, Perrea N., PhD ; Aristides, Zoubos B., MD, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c451t-62eaeeacd6777e7e6804c67b289f8a7ff9ef576af8c6397fe1bc2c5f9cee70ee3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Achilles tendon</topic><topic>Achilles Tendon - drug effects</topic><topic>Achilles Tendon - physiology</topic><topic>Anabolic Agents - pharmacology</topic><topic>Anabolic androgenic steroids</topic><topic>Animals</topic><topic>Biomechanical Phenomena</topic><topic>Biomechanics</topic><topic>Collagen - drug effects</topic><topic>Male</topic><topic>Motor Activity - physiology</topic><topic>Nandrolone - analogs & derivatives</topic><topic>Nandrolone - pharmacology</topic><topic>Orthopedics</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Rupture</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tsitsilonis, Serafim, MD, MSc, PhD</creatorcontrib><creatorcontrib>Panayiotis, Chatzistergos E., PhD</creatorcontrib><creatorcontrib>Athanasios, Mitousoudis S., PhD</creatorcontrib><creatorcontrib>Stavros, Kourkoulis K., PhD</creatorcontrib><creatorcontrib>Ioannis, Vlachos S., MSc</creatorcontrib><creatorcontrib>George, Agrogiannis, MD</creatorcontrib><creatorcontrib>Konstantinos, Fasseas, PhD</creatorcontrib><creatorcontrib>Despina, Perrea N., PhD</creatorcontrib><creatorcontrib>Aristides, Zoubos B., MD, PhD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Foot and ankle surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tsitsilonis, Serafim, MD, MSc, PhD</au><au>Panayiotis, Chatzistergos E., PhD</au><au>Athanasios, Mitousoudis S., PhD</au><au>Stavros, Kourkoulis K., PhD</au><au>Ioannis, Vlachos S., MSc</au><au>George, Agrogiannis, MD</au><au>Konstantinos, Fasseas, PhD</au><au>Despina, Perrea N., PhD</au><au>Aristides, Zoubos B., MD, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anabolic androgenic steroids reverse the beneficial effect of exercise on tendon biomechanics: An experimental study</atitle><jtitle>Foot and ankle surgery</jtitle><addtitle>Foot Ankle Surg</addtitle><date>2014-06-01</date><risdate>2014</risdate><volume>20</volume><issue>2</issue><spage>94</spage><epage>99</epage><pages>94-99</pages><issn>1268-7731</issn><eissn>1460-9584</eissn><abstract>Abstract Background The effect of anabolic androgenic steroids on tendons has not yet been fully elucidated. Aim of the present study was the evaluation of the impact of anabolic androgenic steroids on the biomechanical and histological characteristics of Achilles tendons. Methods Twenty-four male Wistar rats were randomized into four groups with exercise and anabolic steroids (nandrolone decanoate) serving as variables. Protocol duration was 12 weeks. Following euthanasia, tendons’ biomechanical properties were tested with the use of a modified clamping configuration. Histological examination with light and electron microscopy were also performed. Results In the group of anabolic steroids and exercise the lowest fracture stress values were observed, while in the exercise group the highest ones. Histological examination by light and electron microscopy revealed areas of collagen dysplasia and an increased epitendon in the groups receiving anabolic steroids and exercise. Conclusions These findings suggest that anabolic androgenic steroids reverse the beneficial effect of exercise, thus resulting in inferior maximal stress values.</abstract><cop>France</cop><pub>Elsevier Ltd</pub><pmid>24796826</pmid><doi>10.1016/j.fas.2013.12.001</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-6529-6864</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Achilles tendon Achilles Tendon - drug effects Achilles Tendon - physiology Anabolic Agents - pharmacology Anabolic androgenic steroids Animals Biomechanical Phenomena Biomechanics Collagen - drug effects Male Motor Activity - physiology Nandrolone - analogs & derivatives Nandrolone - pharmacology Orthopedics Rats Rats, Wistar Rupture |
| title | Anabolic androgenic steroids reverse the beneficial effect of exercise on tendon biomechanics: An experimental study |
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