Calphostin C (UCN-1028C), a novel microbial compound, is a highly potent and specific inhibitor of protein kinase C

Calphostin C (UCN-1028C), a newly isolated compound from Cladosporium cladosporioides , is a potent and specific inhibitor of protein kinase C, because it was 1000 times more inhibitory to protein kinase C (IC50, 0.05 μM) than other protein kinases such as cAMP-dependent protein kinase and tyrosine-...

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Veröffentlicht in:	Biochemical and biophysical research communications 1989-03, Vol.159 (2), p.548-553
Hauptverfasser:	Kobayashi, Eiji, Nakano, Hirofumi, Morimoto, Makoto, Tamaoki, Tatsuya
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - pharmacology Caenorhabditis elegans Proteins calphostin C Carrier Proteins Cell Division - drug effects Cladosporium - analysis Cladosporium cladosporioides Fungal Proteins - pharmacology HeLa Cells - metabolism Humans Mitosporic Fungi - analysis Naphthalenes Phorbol Esters - metabolism Polycyclic Compounds - pharmacology Protein Kinase C - antagonists & inhibitors Rats Receptors, Drug - drug effects
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