Molecular Cloning and Amino Acid Sequence of Human Plakoglobin, the Common Junctional Plaque Protein
Plakoglobin is a major cytoplasmic protein that occurs in a soluble and a membrane-associated form and is the only known constituent common to the submembranous plaques of both kinds of adhering junctions, the desmosomes and the intermediate junctions. Using a partial cDNA clone for bovine plakoglob...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 1989-06, Vol.86 (11), p.4027-4031 |
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| creator | Franke, Werner W. Goldschmidt, Michaela D. Zimbelmann, Ralf Mueller, Hubert M. Schiller, Dorothea L. Cowin, Pamela |
| description | Plakoglobin is a major cytoplasmic protein that occurs in a soluble and a membrane-associated form and is the only known constituent common to the submembranous plaques of both kinds of adhering junctions, the desmosomes and the intermediate junctions. Using a partial cDNA clone for bovine plakoglobin, we isolated cDNAs encoding human plakoglobin, determined its nucleotide sequence, and deduced the complete amino acid sequence. The polypeptide encoded by the cDNA was synthesized by in vitro transcription and translation and identified by its comigration with authentic plakoglobin in two-dimensional gel electrophoresis. The identity was further confirmed by comparison of the deduced sequence with the directly determined amino acid sequence of two fragments from bovine plakoglobin. Analysis of the plakoglobin sequence showed the protein (744 amino acids; 81,750 Da) to be unrelated to any other known proteins, highly conserved between human and bovine tissues, and characterized by numerous changes between hydrophilic and hydrophobic sections. Only one kind of plakoglobin mRNA (3.4 kilobases) was found in most tissues, but an additional mRNA (3.7 kilobases) was detected in certain human tumor cell lines. This longer mRNA may be represented by a second type of plakoglobin cDNA, which contains an insertion of 297 nucleotides in the 3′noncoding region. |
| doi_str_mv | 10.1073/pnas.86.11.4027 |
| format | Article |
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Using a partial cDNA clone for bovine plakoglobin, we isolated cDNAs encoding human plakoglobin, determined its nucleotide sequence, and deduced the complete amino acid sequence. The polypeptide encoded by the cDNA was synthesized by in vitro transcription and translation and identified by its comigration with authentic plakoglobin in two-dimensional gel electrophoresis. The identity was further confirmed by comparison of the deduced sequence with the directly determined amino acid sequence of two fragments from bovine plakoglobin. Analysis of the plakoglobin sequence showed the protein (744 amino acids; 81,750 Da) to be unrelated to any other known proteins, highly conserved between human and bovine tissues, and characterized by numerous changes between hydrophilic and hydrophobic sections. Only one kind of plakoglobin mRNA (3.4 kilobases) was found in most tissues, but an additional mRNA (3.7 kilobases) was detected in certain human tumor cell lines. This longer mRNA may be represented by a second type of plakoglobin cDNA, which contains an insertion of 297 nucleotides in the 3′noncoding region.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.86.11.4027</identifier><identifier>PMID: 2726765</identifier><identifier>CODEN: PNASA6</identifier><language>eng</language><publisher>Washington, DC: National Academy of Sciences of the United States of America</publisher><subject>550201 - Biochemistry- Tracer Techniques ; AMINO ACID SEQUENCE ; Amino acids ; Animals ; Base Sequence ; BASIC BIOLOGICAL SCIENCES ; BETA DECAY RADIOISOTOPES ; BETA-MINUS DECAY RADIOISOTOPES ; Biochemistry ; Biological and medical sciences ; Cattle ; Cell lines ; CLONING ; Cloning, Molecular ; Complementary DNA ; Cytoskeletal Proteins ; DAYS LIVING RADIOISOTOPES ; Desmoplakins ; Desmosomes - metabolism ; DNA ; DNA HYBRIDIZATION ; DNA SEQUENCING ; DNA-CLONING ; ELECTROPHORESIS ; Epithelial cells ; Fundamental and applied biological sciences. Psychology ; gamma Catenin ; Gels ; genes ; Genes. Genome ; GLOBIN ; Humans ; HYBRIDIZATION ; ISOTOPES ; LIGHT NUCLEI ; man ; Membrane Glycoproteins - genetics ; MESSENGER-RNA ; Molecular and cellular biology ; Molecular genetics ; Molecular Sequence Data ; MOLECULAR STRUCTURE ; NUCLEI ; NUCLEIC ACIDS ; NUCLEOTIDES ; ODD-ODD NUCLEI ; ORGANIC COMPOUNDS ; PHOSPHORUS 32 ; PHOSPHORUS ISOTOPES ; Protein Conformation ; RADIOISOTOPES ; RECOMBINANT DNA ; RNA ; RNA, Messenger - genetics ; Skin - metabolism ; STRUCTURAL CHEMICAL ANALYSIS ; Transcription, Genetic ; Ungulates</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 1989-06, Vol.86 (11), p.4027-4031</ispartof><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c548t-d85390ab8a437788223d6a7113d4464bd0523a21cd320dbff84f0755dc54d8e13</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/86/11.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/33616$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/33616$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,315,728,781,785,804,886,27929,27930,53796,53798,58022,58255</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6925494$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2726765$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/5433974$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Franke, Werner W.</creatorcontrib><creatorcontrib>Goldschmidt, Michaela D.</creatorcontrib><creatorcontrib>Zimbelmann, Ralf</creatorcontrib><creatorcontrib>Mueller, Hubert M.</creatorcontrib><creatorcontrib>Schiller, Dorothea L.</creatorcontrib><creatorcontrib>Cowin, Pamela</creatorcontrib><title>Molecular Cloning and Amino Acid Sequence of Human Plakoglobin, the Common Junctional Plaque Protein</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>Plakoglobin is a major cytoplasmic protein that occurs in a soluble and a membrane-associated form and is the only known constituent common to the submembranous plaques of both kinds of adhering junctions, the desmosomes and the intermediate junctions. Using a partial cDNA clone for bovine plakoglobin, we isolated cDNAs encoding human plakoglobin, determined its nucleotide sequence, and deduced the complete amino acid sequence. The polypeptide encoded by the cDNA was synthesized by in vitro transcription and translation and identified by its comigration with authentic plakoglobin in two-dimensional gel electrophoresis. The identity was further confirmed by comparison of the deduced sequence with the directly determined amino acid sequence of two fragments from bovine plakoglobin. Analysis of the plakoglobin sequence showed the protein (744 amino acids; 81,750 Da) to be unrelated to any other known proteins, highly conserved between human and bovine tissues, and characterized by numerous changes between hydrophilic and hydrophobic sections. Only one kind of plakoglobin mRNA (3.4 kilobases) was found in most tissues, but an additional mRNA (3.7 kilobases) was detected in certain human tumor cell lines. This longer mRNA may be represented by a second type of plakoglobin cDNA, which contains an insertion of 297 nucleotides in the 3′noncoding region.</description><subject>550201 - Biochemistry- Tracer Techniques</subject><subject>AMINO ACID SEQUENCE</subject><subject>Amino acids</subject><subject>Animals</subject><subject>Base Sequence</subject><subject>BASIC BIOLOGICAL SCIENCES</subject><subject>BETA DECAY RADIOISOTOPES</subject><subject>BETA-MINUS DECAY RADIOISOTOPES</subject><subject>Biochemistry</subject><subject>Biological and medical sciences</subject><subject>Cattle</subject><subject>Cell lines</subject><subject>CLONING</subject><subject>Cloning, Molecular</subject><subject>Complementary DNA</subject><subject>Cytoskeletal Proteins</subject><subject>DAYS LIVING RADIOISOTOPES</subject><subject>Desmoplakins</subject><subject>Desmosomes - metabolism</subject><subject>DNA</subject><subject>DNA HYBRIDIZATION</subject><subject>DNA SEQUENCING</subject><subject>DNA-CLONING</subject><subject>ELECTROPHORESIS</subject><subject>Epithelial cells</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>gamma Catenin</subject><subject>Gels</subject><subject>genes</subject><subject>Genes. Genome</subject><subject>GLOBIN</subject><subject>Humans</subject><subject>HYBRIDIZATION</subject><subject>ISOTOPES</subject><subject>LIGHT NUCLEI</subject><subject>man</subject><subject>Membrane Glycoproteins - genetics</subject><subject>MESSENGER-RNA</subject><subject>Molecular and cellular biology</subject><subject>Molecular genetics</subject><subject>Molecular Sequence Data</subject><subject>MOLECULAR STRUCTURE</subject><subject>NUCLEI</subject><subject>NUCLEIC ACIDS</subject><subject>NUCLEOTIDES</subject><subject>ODD-ODD NUCLEI</subject><subject>ORGANIC COMPOUNDS</subject><subject>PHOSPHORUS 32</subject><subject>PHOSPHORUS ISOTOPES</subject><subject>Protein Conformation</subject><subject>RADIOISOTOPES</subject><subject>RECOMBINANT DNA</subject><subject>RNA</subject><subject>RNA, Messenger - genetics</subject><subject>Skin - metabolism</subject><subject>STRUCTURAL CHEMICAL ANALYSIS</subject><subject>Transcription, Genetic</subject><subject>Ungulates</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc-LEzEcxYMoa62eBUEJInpxuvk5yRw8lKKusuKCeg5pkmmzZpLuJCP63ztDx6oXPQXyPu_7_T4eAA8xWmEk6Pkh6ryS9QrjFUNE3AILjBpc1axBt8ECjV-VZITdBfdyvkYINVyiM3BGBKlFzRfAfkjBmSHoHm5Cij7uoI4WrjsfE1wbb-EndzO4aBxMLbwYOh3hVdBf0y6krY8vYdk7uEldlyJ8P0RTfIo6TMjogld9Ks7H--BOq0N2D-Z3Cb68ef15c1Fdfnz7brO-rAxnslRWctogvZWaUSGkJITaWguMqWWsZluLOKGaYGMpQXbbtpK1SHBuR7uVDtMleHWcexi2nbPGxdLroA6973T_QyXt1d9K9Hu1S98UkYLKyf_06E-5eJWNL87sTYrRmaI4o7QRbISez0v6NGbMRXU-GxeCji4NWQnZNIKg5r8g5gRzPGZegvMjaPqUc-_a08UYqallNbWsZK0wVlPLo-Pxn0FP_FzrqD-bdZ2NDm2vo_H5hNUN4ayZoryYsWn-L_X3HtUOIRT3vYzkk3-SI_DoCFznkvoTQWmNa_oTJQ3Qxg</recordid><startdate>19890601</startdate><enddate>19890601</enddate><creator>Franke, Werner W.</creator><creator>Goldschmidt, Michaela D.</creator><creator>Zimbelmann, Ralf</creator><creator>Mueller, Hubert M.</creator><creator>Schiller, Dorothea L.</creator><creator>Cowin, Pamela</creator><general>National Academy of Sciences of the United States of America</general><general>National Acad Sciences</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7TM</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>M81</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>OTOTI</scope><scope>5PM</scope></search><sort><creationdate>19890601</creationdate><title>Molecular Cloning and Amino Acid Sequence of Human Plakoglobin, the Common Junctional Plaque Protein</title><author>Franke, Werner W. ; Goldschmidt, Michaela D. ; Zimbelmann, Ralf ; Mueller, Hubert M. ; Schiller, Dorothea L. ; Cowin, Pamela</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c548t-d85390ab8a437788223d6a7113d4464bd0523a21cd320dbff84f0755dc54d8e13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>550201 - Biochemistry- Tracer Techniques</topic><topic>AMINO ACID SEQUENCE</topic><topic>Amino acids</topic><topic>Animals</topic><topic>Base Sequence</topic><topic>BASIC BIOLOGICAL SCIENCES</topic><topic>BETA DECAY RADIOISOTOPES</topic><topic>BETA-MINUS DECAY RADIOISOTOPES</topic><topic>Biochemistry</topic><topic>Biological and medical sciences</topic><topic>Cattle</topic><topic>Cell lines</topic><topic>CLONING</topic><topic>Cloning, Molecular</topic><topic>Complementary DNA</topic><topic>Cytoskeletal Proteins</topic><topic>DAYS LIVING RADIOISOTOPES</topic><topic>Desmoplakins</topic><topic>Desmosomes - metabolism</topic><topic>DNA</topic><topic>DNA HYBRIDIZATION</topic><topic>DNA SEQUENCING</topic><topic>DNA-CLONING</topic><topic>ELECTROPHORESIS</topic><topic>Epithelial cells</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>gamma Catenin</topic><topic>Gels</topic><topic>genes</topic><topic>Genes. Genome</topic><topic>GLOBIN</topic><topic>Humans</topic><topic>HYBRIDIZATION</topic><topic>ISOTOPES</topic><topic>LIGHT NUCLEI</topic><topic>man</topic><topic>Membrane Glycoproteins - genetics</topic><topic>MESSENGER-RNA</topic><topic>Molecular and cellular biology</topic><topic>Molecular genetics</topic><topic>Molecular Sequence Data</topic><topic>MOLECULAR STRUCTURE</topic><topic>NUCLEI</topic><topic>NUCLEIC ACIDS</topic><topic>NUCLEOTIDES</topic><topic>ODD-ODD NUCLEI</topic><topic>ORGANIC COMPOUNDS</topic><topic>PHOSPHORUS 32</topic><topic>PHOSPHORUS ISOTOPES</topic><topic>Protein Conformation</topic><topic>RADIOISOTOPES</topic><topic>RECOMBINANT DNA</topic><topic>RNA</topic><topic>RNA, Messenger - genetics</topic><topic>Skin - metabolism</topic><topic>STRUCTURAL CHEMICAL ANALYSIS</topic><topic>Transcription, Genetic</topic><topic>Ungulates</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Franke, Werner W.</creatorcontrib><creatorcontrib>Goldschmidt, Michaela D.</creatorcontrib><creatorcontrib>Zimbelmann, Ralf</creatorcontrib><creatorcontrib>Mueller, Hubert M.</creatorcontrib><creatorcontrib>Schiller, Dorothea L.</creatorcontrib><creatorcontrib>Cowin, Pamela</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biochemistry Abstracts 3</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Franke, Werner W.</au><au>Goldschmidt, Michaela D.</au><au>Zimbelmann, Ralf</au><au>Mueller, Hubert M.</au><au>Schiller, Dorothea L.</au><au>Cowin, Pamela</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Molecular Cloning and Amino Acid Sequence of Human Plakoglobin, the Common Junctional Plaque Protein</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>1989-06-01</date><risdate>1989</risdate><volume>86</volume><issue>11</issue><spage>4027</spage><epage>4031</epage><pages>4027-4031</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><coden>PNASA6</coden><abstract>Plakoglobin is a major cytoplasmic protein that occurs in a soluble and a membrane-associated form and is the only known constituent common to the submembranous plaques of both kinds of adhering junctions, the desmosomes and the intermediate junctions. Using a partial cDNA clone for bovine plakoglobin, we isolated cDNAs encoding human plakoglobin, determined its nucleotide sequence, and deduced the complete amino acid sequence. The polypeptide encoded by the cDNA was synthesized by in vitro transcription and translation and identified by its comigration with authentic plakoglobin in two-dimensional gel electrophoresis. The identity was further confirmed by comparison of the deduced sequence with the directly determined amino acid sequence of two fragments from bovine plakoglobin. Analysis of the plakoglobin sequence showed the protein (744 amino acids; 81,750 Da) to be unrelated to any other known proteins, highly conserved between human and bovine tissues, and characterized by numerous changes between hydrophilic and hydrophobic sections. Only one kind of plakoglobin mRNA (3.4 kilobases) was found in most tissues, but an additional mRNA (3.7 kilobases) was detected in certain human tumor cell lines. This longer mRNA may be represented by a second type of plakoglobin cDNA, which contains an insertion of 297 nucleotides in the 3′noncoding region.</abstract><cop>Washington, DC</cop><pub>National Academy of Sciences of the United States of America</pub><pmid>2726765</pmid><doi>10.1073/pnas.86.11.4027</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Proceedings of the National Academy of Sciences - PNAS, 1989-06, Vol.86 (11), p.4027-4031 |
| issn | 0027-8424 1091-6490 |
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| recordid | cdi_proquest_miscellaneous_15215185 |
| source | MEDLINE; Jstor Complete Legacy; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | 550201 - Biochemistry- Tracer Techniques AMINO ACID SEQUENCE Amino acids Animals Base Sequence BASIC BIOLOGICAL SCIENCES BETA DECAY RADIOISOTOPES BETA-MINUS DECAY RADIOISOTOPES Biochemistry Biological and medical sciences Cattle Cell lines CLONING Cloning, Molecular Complementary DNA Cytoskeletal Proteins DAYS LIVING RADIOISOTOPES Desmoplakins Desmosomes - metabolism DNA DNA HYBRIDIZATION DNA SEQUENCING DNA-CLONING ELECTROPHORESIS Epithelial cells Fundamental and applied biological sciences. Psychology gamma Catenin Gels genes Genes. Genome GLOBIN Humans HYBRIDIZATION ISOTOPES LIGHT NUCLEI man Membrane Glycoproteins - genetics MESSENGER-RNA Molecular and cellular biology Molecular genetics Molecular Sequence Data MOLECULAR STRUCTURE NUCLEI NUCLEIC ACIDS NUCLEOTIDES ODD-ODD NUCLEI ORGANIC COMPOUNDS PHOSPHORUS 32 PHOSPHORUS ISOTOPES Protein Conformation RADIOISOTOPES RECOMBINANT DNA RNA RNA, Messenger - genetics Skin - metabolism STRUCTURAL CHEMICAL ANALYSIS Transcription, Genetic Ungulates |
| title | Molecular Cloning and Amino Acid Sequence of Human Plakoglobin, the Common Junctional Plaque Protein |
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