2-Bromo-(diglutathion-S-yl)hydroquinone nephrotoxicity: physiological, biochemical, and electrochemical determinants

2-Bromo-(diglutathion-S-yl)hydroquinone [2-Br-(diGSyl)HQ] causes severe necrosis of the proximal renal tubules in the rat, elevations in blood urea nitrogen (BUN) and increased urinary excretion of protein, glucose, and lactate dehydrogenase. In contrast, 2-Br-3-(GSyl)HQ, 2-Br-5-(GSyl)HQ, and 2-Br-6...

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Veröffentlicht in:	Molecular pharmacology 1988-10, Vol.34 (4), p.492-500
Hauptverfasser:	MONKS, T. J, HIGHET, R. J, LAU, S. S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Biological Transport Biotransformation Glutathione - analogs & derivatives Glutathione - toxicity Hydroquinones - toxicity Isomerism Kidney - drug effects Kidney - metabolism Kidney Tubules - metabolism Magnetic Resonance Spectroscopy Male Medical sciences Oxidation-Reduction Pharmacology. Drug treatments Rats Structure-Activity Relationship
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