Complete androgen insensitivity syndrome: factors influencing gonadal histology including germ cell pathology

Patients with complete androgen insensitivity syndrome are at an increased risk for the development of gonadal germ cell cancer. Residual androgen receptor (AR) activity and abnormal gonadal location may influence the survival of atypical germ cells and the development of other histopathological fea...

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Veröffentlicht in:	Modern pathology 2014-05, Vol.27 (5), p.721-730
Hauptverfasser:	Kaprova-Pleskacova, Jana, Stoop, Hans, Brüggenwirth, Hennie, Cools, Martine, Wolffenbuttel, Katja P, Drop, Stenvert LS, Snajderova, Marta, Lebl, Jan, Oosterhuis, J Wolter, Looijenga, Leendert HJ
Format:	Artikel
Sprache:	eng
Schlagworte:	692/698/690/1520 692/699/2732/2731 692/700/139/422 Adolescent Age Androgen-Insensitivity Syndrome - pathology Androgens Cancer Child Child, Preschool complete androgen insensitivity syndrome delayed germ cell maturation Endocrinology Germ Cells - pathology gonads Histology Humans Infant intratubular germ cell neoplasia Investigations KITLG Laboratory Medicine Ligands Male Medicine Medicine & Public Health Mutation Neoplasms, Germ Cell and Embryonal - pathology original-article Pathology Pediatrics POU5F1 Testicular Neoplasms - pathology Testis - pathology
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