Human embryos secrete microRNAs into culture media—a potential biomarker for implantation

Objective To determine whether human blastocysts secrete microRNA (miRNAs) into culture media and whether these reflect embryonic ploidy status and can predict in vitro fertilization (IVF) outcomes. Design Experimental study of human embryos and IVF culture media. Setting Academic IVF program. Patie...

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Veröffentlicht in:	Fertility and sterility 2014-05, Vol.101 (5), p.1493-1500
Hauptverfasser:	Rosenbluth, Evan M., M.D, Shelton, Dawne N., Ph.D, Wells, Lindsay M., M.D, Sparks, Amy E.T., Ph.D, Van Voorhis, Bradley J., M.D
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarkers - metabolism Cohort Studies Cryopreservation - methods Embryo Culture Techniques - methods Embryo Implantation - genetics Embryo Transfer - methods exosomes Expression Female human blastocyst Humans Internal Medicine IVF Male media microRNA MicroRNAs - biosynthesis MicroRNAs - secretion Obstetrics and Gynecology Pregnancy Pregnancy Rate - trends secretion
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