Loss of HIF-1α impairs GLUT4 translocation and glucose uptake by the skeletal muscle cells
Defects in glucose uptake by the skeletal muscle cause diseases linked to metabolic disturbance such as type 2 diabetes. The molecular mechanism determining glucose disposal in the skeletal muscle in response to cellular stimuli including insulin, however, remains largely unknown. The hypoxia-induci...
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Veröffentlicht in: | American journal of physiology: endocrinology and metabolism 2014-05, Vol.306 (9), p.E1065-E1076 |
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Sprache: | eng |
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