A genetic variant in the region of MMP-9 is associated with serum levels and progression of joint damage in rheumatoid arthritis

Objectives The severity of joint destruction is highly variable between rheumatoid arthritis (RA) patients. The majority of its heritability is still unexplained. Several autoimmune diseases share genetic risk variants that may also influence disease progression. We aimed to identify genetic risk fa...

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Veröffentlicht in:	Annals of the rheumatic diseases 2014-06, Vol.73 (6), p.1163-1169
Hauptverfasser:	de Rooy, D P C, Zhernakova, A, Tsonaka, R, Willemze, A, Kurreeman, B A S, Trynka, G, van Toorn, L, Toes, R E M, Huizinga, T W J, Houwing-Duistermaat, J J, Gregersen, P K, van der Helm-van Mil, A H M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Arthritis, Rheumatoid - blood Arthritis, Rheumatoid - diagnostic imaging Arthritis, Rheumatoid - genetics Autoimmune diseases Disease Disease Progression Female Foot Joints - diagnostic imaging Gender Genetic Predisposition to Disease Genomes Genotype Hand Joints - diagnostic imaging Humans Hypotheses Male Matrix Metalloproteinase 9 - blood Matrix Metalloproteinase 9 - genetics Middle Aged Patients Polymorphism, Single Nucleotide Quality control Radiography Rheumatism Rheumatology Severity of Illness Index Studies
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