Human Basic Fibroblast Growth Factor Gene Encodes Four Polypeptides: Three Initiate Translation from Non-AUG Codons

Human basic fibroblast growth factor (bFGF) is an angiogenic polypeptide mitogen present in a wide variety of mesoderm- and neuroectoderm-derived tissues. bFGF cDNA and genomic clones predict a 17.8-kDa (155-amino acid) gene product based on the presence of a single putative translational initiator...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1989-06, Vol.86 (11), p.3978-3981
Hauptverfasser:	Florkiewicz, Robert Z., Sommer, Andreas
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 cells 550201 - Biochemistry- Tracer Techniques AMINO ACIDS ANIMAL CELLS Animals Antibodies AZINES Base Sequence BASIC BIOLOGICAL SCIENCES BETA DECAY RADIOISOTOPES BETA-MINUS DECAY RADIOISOTOPES BIOCHEMISTRY Biological and medical sciences CARBOXYLIC ACIDS Cell Line Cell lines CHEMISTRY Codon - genetics CODONS Complementary DNA CONNECTIVE TISSUE CELLS COS cells DAYS LIVING RADIOISOTOPES DNA DNA SEQUENCING DRUGS EVEN-ODD NUCLEI Female FETAL MEMBRANES Fibroblast Growth Factors - genetics FIBROBLASTS Fundamental and applied biological sciences. Psychology GENE REGULATION GENES Genetic mutation GROWTH FACTORS HETEROCYCLIC COMPOUNDS Humans HYDROGEN COMPOUNDS ISOTOPES LIGHT NUCLEI LIPOTROPIC FACTORS MEMBRANES MESSENGER-RNA METHIONINE MITOGENS Molecular and cellular biology Molecular genetics Molecular Sequence Data Molecular weight MUTAGENESIS Mutation NUCLEI NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ODD-ODD NUCLEI ORGANIC ACIDS ORGANIC COMPOUNDS ORGANIC NITROGEN COMPOUNDS ORGANIC SULFUR COMPOUNDS Peptide Chain Initiation, Translational PEPTIDES PHOSPHORUS 32 PHOSPHORUS ISOTOPES PLACENTA Placenta - metabolism POLYPEPTIDES Pregnancy Protein Biosynthesis PROTEINS PYRIMIDINES RADIOISOTOPES RECOMBINANT DNA RIBOSIDES RNA RNA, Messenger - genetics SOMATIC CELLS STRUCTURAL CHEMICAL ANALYSIS SULFUR 35 SULFUR ISOTOPES THYMIDINE Transcription, Genetic Transfection Translation. Translation factors. Protein processing TRITIUM COMPOUNDS
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