Human Basic Fibroblast Growth Factor Gene Encodes Four Polypeptides: Three Initiate Translation from Non-AUG Codons
Human basic fibroblast growth factor (bFGF) is an angiogenic polypeptide mitogen present in a wide variety of mesoderm- and neuroectoderm-derived tissues. bFGF cDNA and genomic clones predict a 17.8-kDa (155-amino acid) gene product based on the presence of a single putative translational initiator...
Gespeichert in:
| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 1989-06, Vol.86 (11), p.3978-3981 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 3981 |
|---|---|
| container_issue | 11 |
| container_start_page | 3978 |
| container_title | Proceedings of the National Academy of Sciences - PNAS |
| container_volume | 86 |
| creator | Florkiewicz, Robert Z. Sommer, Andreas |
| description | Human basic fibroblast growth factor (bFGF) is an angiogenic polypeptide mitogen present in a wide variety of mesoderm- and neuroectoderm-derived tissues. bFGF cDNA and genomic clones predict a 17.8-kDa (155-amino acid) gene product based on the presence of a single putative translational initiator ATG codon. However, a bFGF protein isolated from human placenta contains two additional amino acids NH2-terminal to the predicted initiator methionine. We report here that the human cell line SK-HEP-1 coexpresses four molecular forms (17.8, 22.5, 23.1, and 24.2 kDa) of bFGF. The 17.8-kDa bFGF protein is translationally initiated at the previously predicted methionine (AUG) codon, whereas the 22.5-, 23.1-, and 24.2-kDa proteins initiate at unusual non-AUG codons. The higher molecular weight forms are colinear NH2-terminal extensions of the 18-kDa bFGF. |
| doi_str_mv | 10.1073/pnas.86.11.3978 |
| format | Article |
| fullrecord | <record><control><sourceid>jstor_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_15209009</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>33606</jstor_id><sourcerecordid>33606</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5298-728602377b5d4738069799161e501586927e4c0995891cb9b0e6ba79a0d163c03</originalsourceid><addsrcrecordid>eNqFks2LEzEYxgdR1rp6FgQliOhpum-STj4ED2vZdhcW9dA9h0wmY7NMk26SUfe_N6W1uBc9BfL8nvcjT6rqJYYpBk7Ptl6nqWBTjKdUcvGommCQuGYzCY-rCQDhtZiR2dPqWUq3ACAbASfVCeGEcYYnVbocN9qjzzo5gxaujaEddMpoGcPPvEYLbXKIaGm9RRfehM4mtAhjRN_CcL-12-zKzUe0Wkdr0ZV32els0SpqnwadXfCoj2GDvgRfn98s0Tx0wafn1ZNeD8m-OJyn1c3iYjW_rK-_Lq_m59e1aYgUNSeCAaGct00341QAk1xKzLBtADeCScLtzIAsK0lsWtmCZa3mUkOHGTVAT6tP-7rbsd3Yzlifox7UNrqNjvcqaKceKt6t1ffwQxHBKcfF_3bvDyk7lYzL1qxN8N6arBpCBJWsQO8PTWK4G23KauOSscOgvQ1jUlyUmSkm_wVxQ0CWgAp4tgdNDClF2x8nxqB2oatd6EowhbHahV4cr_9e9MgfUi76u4Ouk9FDX-IxLh0xVh6VQVOwNwdsV_-P-qDPh38Cqh-HIdtfuZCv9uRtKv_niFLKgNHff3fU1w</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>15209009</pqid></control><display><type>article</type><title>Human Basic Fibroblast Growth Factor Gene Encodes Four Polypeptides: Three Initiate Translation from Non-AUG Codons</title><source>MEDLINE</source><source>Jstor Complete Legacy</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><source>Free Full-Text Journals in Chemistry</source><creator>Florkiewicz, Robert Z. ; Sommer, Andreas</creator><creatorcontrib>Florkiewicz, Robert Z. ; Sommer, Andreas</creatorcontrib><description>Human basic fibroblast growth factor (bFGF) is an angiogenic polypeptide mitogen present in a wide variety of mesoderm- and neuroectoderm-derived tissues. bFGF cDNA and genomic clones predict a 17.8-kDa (155-amino acid) gene product based on the presence of a single putative translational initiator ATG codon. However, a bFGF protein isolated from human placenta contains two additional amino acids NH2-terminal to the predicted initiator methionine. We report here that the human cell line SK-HEP-1 coexpresses four molecular forms (17.8, 22.5, 23.1, and 24.2 kDa) of bFGF. The 17.8-kDa bFGF protein is translationally initiated at the previously predicted methionine (AUG) codon, whereas the 22.5-, 23.1-, and 24.2-kDa proteins initiate at unusual non-AUG codons. The higher molecular weight forms are colinear NH2-terminal extensions of the 18-kDa bFGF.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.86.11.3978</identifier><identifier>PMID: 2726761</identifier><identifier>CODEN: PNASA6</identifier><language>eng</language><publisher>Washington, DC: National Academy of Sciences of the United States of America</publisher><subject>3T3 cells ; 550201 - Biochemistry- Tracer Techniques ; AMINO ACIDS ; ANIMAL CELLS ; Animals ; Antibodies ; AZINES ; Base Sequence ; BASIC BIOLOGICAL SCIENCES ; BETA DECAY RADIOISOTOPES ; BETA-MINUS DECAY RADIOISOTOPES ; BIOCHEMISTRY ; Biological and medical sciences ; CARBOXYLIC ACIDS ; Cell Line ; Cell lines ; CHEMISTRY ; Codon - genetics ; CODONS ; Complementary DNA ; CONNECTIVE TISSUE CELLS ; COS cells ; DAYS LIVING RADIOISOTOPES ; DNA ; DNA SEQUENCING ; DRUGS ; EVEN-ODD NUCLEI ; Female ; FETAL MEMBRANES ; Fibroblast Growth Factors - genetics ; FIBROBLASTS ; Fundamental and applied biological sciences. Psychology ; GENE REGULATION ; GENES ; Genetic mutation ; GROWTH FACTORS ; HETEROCYCLIC COMPOUNDS ; Humans ; HYDROGEN COMPOUNDS ; ISOTOPES ; LIGHT NUCLEI ; LIPOTROPIC FACTORS ; MEMBRANES ; MESSENGER-RNA ; METHIONINE ; MITOGENS ; Molecular and cellular biology ; Molecular genetics ; Molecular Sequence Data ; Molecular weight ; MUTAGENESIS ; Mutation ; NUCLEI ; NUCLEIC ACIDS ; NUCLEOSIDES ; NUCLEOTIDES ; ODD-ODD NUCLEI ; ORGANIC ACIDS ; ORGANIC COMPOUNDS ; ORGANIC NITROGEN COMPOUNDS ; ORGANIC SULFUR COMPOUNDS ; Peptide Chain Initiation, Translational ; PEPTIDES ; PHOSPHORUS 32 ; PHOSPHORUS ISOTOPES ; PLACENTA ; Placenta - metabolism ; POLYPEPTIDES ; Pregnancy ; Protein Biosynthesis ; PROTEINS ; PYRIMIDINES ; RADIOISOTOPES ; RECOMBINANT DNA ; RIBOSIDES ; RNA ; RNA, Messenger - genetics ; SOMATIC CELLS ; STRUCTURAL CHEMICAL ANALYSIS ; SULFUR 35 ; SULFUR ISOTOPES ; THYMIDINE ; Transcription, Genetic ; Transfection ; Translation. Translation factors. Protein processing ; TRITIUM COMPOUNDS</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 1989-06, Vol.86 (11), p.3978-3981</ispartof><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5298-728602377b5d4738069799161e501586927e4c0995891cb9b0e6ba79a0d163c03</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/86/11.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/33606$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/33606$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,723,776,780,799,881,27903,27904,53769,53771,57995,58228</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6916605$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2726761$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/5228396$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Florkiewicz, Robert Z.</creatorcontrib><creatorcontrib>Sommer, Andreas</creatorcontrib><title>Human Basic Fibroblast Growth Factor Gene Encodes Four Polypeptides: Three Initiate Translation from Non-AUG Codons</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>Human basic fibroblast growth factor (bFGF) is an angiogenic polypeptide mitogen present in a wide variety of mesoderm- and neuroectoderm-derived tissues. bFGF cDNA and genomic clones predict a 17.8-kDa (155-amino acid) gene product based on the presence of a single putative translational initiator ATG codon. However, a bFGF protein isolated from human placenta contains two additional amino acids NH2-terminal to the predicted initiator methionine. We report here that the human cell line SK-HEP-1 coexpresses four molecular forms (17.8, 22.5, 23.1, and 24.2 kDa) of bFGF. The 17.8-kDa bFGF protein is translationally initiated at the previously predicted methionine (AUG) codon, whereas the 22.5-, 23.1-, and 24.2-kDa proteins initiate at unusual non-AUG codons. The higher molecular weight forms are colinear NH2-terminal extensions of the 18-kDa bFGF.</description><subject>3T3 cells</subject><subject>550201 - Biochemistry- Tracer Techniques</subject><subject>AMINO ACIDS</subject><subject>ANIMAL CELLS</subject><subject>Animals</subject><subject>Antibodies</subject><subject>AZINES</subject><subject>Base Sequence</subject><subject>BASIC BIOLOGICAL SCIENCES</subject><subject>BETA DECAY RADIOISOTOPES</subject><subject>BETA-MINUS DECAY RADIOISOTOPES</subject><subject>BIOCHEMISTRY</subject><subject>Biological and medical sciences</subject><subject>CARBOXYLIC ACIDS</subject><subject>Cell Line</subject><subject>Cell lines</subject><subject>CHEMISTRY</subject><subject>Codon - genetics</subject><subject>CODONS</subject><subject>Complementary DNA</subject><subject>CONNECTIVE TISSUE CELLS</subject><subject>COS cells</subject><subject>DAYS LIVING RADIOISOTOPES</subject><subject>DNA</subject><subject>DNA SEQUENCING</subject><subject>DRUGS</subject><subject>EVEN-ODD NUCLEI</subject><subject>Female</subject><subject>FETAL MEMBRANES</subject><subject>Fibroblast Growth Factors - genetics</subject><subject>FIBROBLASTS</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>GENE REGULATION</subject><subject>GENES</subject><subject>Genetic mutation</subject><subject>GROWTH FACTORS</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>Humans</subject><subject>HYDROGEN COMPOUNDS</subject><subject>ISOTOPES</subject><subject>LIGHT NUCLEI</subject><subject>LIPOTROPIC FACTORS</subject><subject>MEMBRANES</subject><subject>MESSENGER-RNA</subject><subject>METHIONINE</subject><subject>MITOGENS</subject><subject>Molecular and cellular biology</subject><subject>Molecular genetics</subject><subject>Molecular Sequence Data</subject><subject>Molecular weight</subject><subject>MUTAGENESIS</subject><subject>Mutation</subject><subject>NUCLEI</subject><subject>NUCLEIC ACIDS</subject><subject>NUCLEOSIDES</subject><subject>NUCLEOTIDES</subject><subject>ODD-ODD NUCLEI</subject><subject>ORGANIC ACIDS</subject><subject>ORGANIC COMPOUNDS</subject><subject>ORGANIC NITROGEN COMPOUNDS</subject><subject>ORGANIC SULFUR COMPOUNDS</subject><subject>Peptide Chain Initiation, Translational</subject><subject>PEPTIDES</subject><subject>PHOSPHORUS 32</subject><subject>PHOSPHORUS ISOTOPES</subject><subject>PLACENTA</subject><subject>Placenta - metabolism</subject><subject>POLYPEPTIDES</subject><subject>Pregnancy</subject><subject>Protein Biosynthesis</subject><subject>PROTEINS</subject><subject>PYRIMIDINES</subject><subject>RADIOISOTOPES</subject><subject>RECOMBINANT DNA</subject><subject>RIBOSIDES</subject><subject>RNA</subject><subject>RNA, Messenger - genetics</subject><subject>SOMATIC CELLS</subject><subject>STRUCTURAL CHEMICAL ANALYSIS</subject><subject>SULFUR 35</subject><subject>SULFUR ISOTOPES</subject><subject>THYMIDINE</subject><subject>Transcription, Genetic</subject><subject>Transfection</subject><subject>Translation. Translation factors. Protein processing</subject><subject>TRITIUM COMPOUNDS</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFks2LEzEYxgdR1rp6FgQliOhpum-STj4ED2vZdhcW9dA9h0wmY7NMk26SUfe_N6W1uBc9BfL8nvcjT6rqJYYpBk7Ptl6nqWBTjKdUcvGommCQuGYzCY-rCQDhtZiR2dPqWUq3ACAbASfVCeGEcYYnVbocN9qjzzo5gxaujaEddMpoGcPPvEYLbXKIaGm9RRfehM4mtAhjRN_CcL-12-zKzUe0Wkdr0ZV32els0SpqnwadXfCoj2GDvgRfn98s0Tx0wafn1ZNeD8m-OJyn1c3iYjW_rK-_Lq_m59e1aYgUNSeCAaGct00341QAk1xKzLBtADeCScLtzIAsK0lsWtmCZa3mUkOHGTVAT6tP-7rbsd3Yzlifox7UNrqNjvcqaKceKt6t1ffwQxHBKcfF_3bvDyk7lYzL1qxN8N6arBpCBJWsQO8PTWK4G23KauOSscOgvQ1jUlyUmSkm_wVxQ0CWgAp4tgdNDClF2x8nxqB2oatd6EowhbHahV4cr_9e9MgfUi76u4Ouk9FDX-IxLh0xVh6VQVOwNwdsV_-P-qDPh38Cqh-HIdtfuZCv9uRtKv_niFLKgNHff3fU1w</recordid><startdate>19890601</startdate><enddate>19890601</enddate><creator>Florkiewicz, Robert Z.</creator><creator>Sommer, Andreas</creator><general>National Academy of Sciences of the United States of America</general><general>National Acad Sciences</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>7TO</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>OTOTI</scope><scope>5PM</scope></search><sort><creationdate>19890601</creationdate><title>Human Basic Fibroblast Growth Factor Gene Encodes Four Polypeptides: Three Initiate Translation from Non-AUG Codons</title><author>Florkiewicz, Robert Z. ; Sommer, Andreas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5298-728602377b5d4738069799161e501586927e4c0995891cb9b0e6ba79a0d163c03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>3T3 cells</topic><topic>550201 - Biochemistry- Tracer Techniques</topic><topic>AMINO ACIDS</topic><topic>ANIMAL CELLS</topic><topic>Animals</topic><topic>Antibodies</topic><topic>AZINES</topic><topic>Base Sequence</topic><topic>BASIC BIOLOGICAL SCIENCES</topic><topic>BETA DECAY RADIOISOTOPES</topic><topic>BETA-MINUS DECAY RADIOISOTOPES</topic><topic>BIOCHEMISTRY</topic><topic>Biological and medical sciences</topic><topic>CARBOXYLIC ACIDS</topic><topic>Cell Line</topic><topic>Cell lines</topic><topic>CHEMISTRY</topic><topic>Codon - genetics</topic><topic>CODONS</topic><topic>Complementary DNA</topic><topic>CONNECTIVE TISSUE CELLS</topic><topic>COS cells</topic><topic>DAYS LIVING RADIOISOTOPES</topic><topic>DNA</topic><topic>DNA SEQUENCING</topic><topic>DRUGS</topic><topic>EVEN-ODD NUCLEI</topic><topic>Female</topic><topic>FETAL MEMBRANES</topic><topic>Fibroblast Growth Factors - genetics</topic><topic>FIBROBLASTS</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>GENE REGULATION</topic><topic>GENES</topic><topic>Genetic mutation</topic><topic>GROWTH FACTORS</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>Humans</topic><topic>HYDROGEN COMPOUNDS</topic><topic>ISOTOPES</topic><topic>LIGHT NUCLEI</topic><topic>LIPOTROPIC FACTORS</topic><topic>MEMBRANES</topic><topic>MESSENGER-RNA</topic><topic>METHIONINE</topic><topic>MITOGENS</topic><topic>Molecular and cellular biology</topic><topic>Molecular genetics</topic><topic>Molecular Sequence Data</topic><topic>Molecular weight</topic><topic>MUTAGENESIS</topic><topic>Mutation</topic><topic>NUCLEI</topic><topic>NUCLEIC ACIDS</topic><topic>NUCLEOSIDES</topic><topic>NUCLEOTIDES</topic><topic>ODD-ODD NUCLEI</topic><topic>ORGANIC ACIDS</topic><topic>ORGANIC COMPOUNDS</topic><topic>ORGANIC NITROGEN COMPOUNDS</topic><topic>ORGANIC SULFUR COMPOUNDS</topic><topic>Peptide Chain Initiation, Translational</topic><topic>PEPTIDES</topic><topic>PHOSPHORUS 32</topic><topic>PHOSPHORUS ISOTOPES</topic><topic>PLACENTA</topic><topic>Placenta - metabolism</topic><topic>POLYPEPTIDES</topic><topic>Pregnancy</topic><topic>Protein Biosynthesis</topic><topic>PROTEINS</topic><topic>PYRIMIDINES</topic><topic>RADIOISOTOPES</topic><topic>RECOMBINANT DNA</topic><topic>RIBOSIDES</topic><topic>RNA</topic><topic>RNA, Messenger - genetics</topic><topic>SOMATIC CELLS</topic><topic>STRUCTURAL CHEMICAL ANALYSIS</topic><topic>SULFUR 35</topic><topic>SULFUR ISOTOPES</topic><topic>THYMIDINE</topic><topic>Transcription, Genetic</topic><topic>Transfection</topic><topic>Translation. Translation factors. Protein processing</topic><topic>TRITIUM COMPOUNDS</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Florkiewicz, Robert Z.</creatorcontrib><creatorcontrib>Sommer, Andreas</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Florkiewicz, Robert Z.</au><au>Sommer, Andreas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Human Basic Fibroblast Growth Factor Gene Encodes Four Polypeptides: Three Initiate Translation from Non-AUG Codons</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>1989-06-01</date><risdate>1989</risdate><volume>86</volume><issue>11</issue><spage>3978</spage><epage>3981</epage><pages>3978-3981</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><coden>PNASA6</coden><abstract>Human basic fibroblast growth factor (bFGF) is an angiogenic polypeptide mitogen present in a wide variety of mesoderm- and neuroectoderm-derived tissues. bFGF cDNA and genomic clones predict a 17.8-kDa (155-amino acid) gene product based on the presence of a single putative translational initiator ATG codon. However, a bFGF protein isolated from human placenta contains two additional amino acids NH2-terminal to the predicted initiator methionine. We report here that the human cell line SK-HEP-1 coexpresses four molecular forms (17.8, 22.5, 23.1, and 24.2 kDa) of bFGF. The 17.8-kDa bFGF protein is translationally initiated at the previously predicted methionine (AUG) codon, whereas the 22.5-, 23.1-, and 24.2-kDa proteins initiate at unusual non-AUG codons. The higher molecular weight forms are colinear NH2-terminal extensions of the 18-kDa bFGF.</abstract><cop>Washington, DC</cop><pub>National Academy of Sciences of the United States of America</pub><pmid>2726761</pmid><doi>10.1073/pnas.86.11.3978</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0027-8424 |
| ispartof | Proceedings of the National Academy of Sciences - PNAS, 1989-06, Vol.86 (11), p.3978-3981 |
| issn | 0027-8424 1091-6490 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_15209009 |
| source | MEDLINE; Jstor Complete Legacy; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | 3T3 cells 550201 - Biochemistry- Tracer Techniques AMINO ACIDS ANIMAL CELLS Animals Antibodies AZINES Base Sequence BASIC BIOLOGICAL SCIENCES BETA DECAY RADIOISOTOPES BETA-MINUS DECAY RADIOISOTOPES BIOCHEMISTRY Biological and medical sciences CARBOXYLIC ACIDS Cell Line Cell lines CHEMISTRY Codon - genetics CODONS Complementary DNA CONNECTIVE TISSUE CELLS COS cells DAYS LIVING RADIOISOTOPES DNA DNA SEQUENCING DRUGS EVEN-ODD NUCLEI Female FETAL MEMBRANES Fibroblast Growth Factors - genetics FIBROBLASTS Fundamental and applied biological sciences. Psychology GENE REGULATION GENES Genetic mutation GROWTH FACTORS HETEROCYCLIC COMPOUNDS Humans HYDROGEN COMPOUNDS ISOTOPES LIGHT NUCLEI LIPOTROPIC FACTORS MEMBRANES MESSENGER-RNA METHIONINE MITOGENS Molecular and cellular biology Molecular genetics Molecular Sequence Data Molecular weight MUTAGENESIS Mutation NUCLEI NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ODD-ODD NUCLEI ORGANIC ACIDS ORGANIC COMPOUNDS ORGANIC NITROGEN COMPOUNDS ORGANIC SULFUR COMPOUNDS Peptide Chain Initiation, Translational PEPTIDES PHOSPHORUS 32 PHOSPHORUS ISOTOPES PLACENTA Placenta - metabolism POLYPEPTIDES Pregnancy Protein Biosynthesis PROTEINS PYRIMIDINES RADIOISOTOPES RECOMBINANT DNA RIBOSIDES RNA RNA, Messenger - genetics SOMATIC CELLS STRUCTURAL CHEMICAL ANALYSIS SULFUR 35 SULFUR ISOTOPES THYMIDINE Transcription, Genetic Transfection Translation. Translation factors. Protein processing TRITIUM COMPOUNDS |
| title | Human Basic Fibroblast Growth Factor Gene Encodes Four Polypeptides: Three Initiate Translation from Non-AUG Codons |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-25T07%3A21%3A39IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Human%20Basic%20Fibroblast%20Growth%20Factor%20Gene%20Encodes%20Four%20Polypeptides:%20Three%20Initiate%20Translation%20from%20Non-AUG%20Codons&rft.jtitle=Proceedings%20of%20the%20National%20Academy%20of%20Sciences%20-%20PNAS&rft.au=Florkiewicz,%20Robert%20Z.&rft.date=1989-06-01&rft.volume=86&rft.issue=11&rft.spage=3978&rft.epage=3981&rft.pages=3978-3981&rft.issn=0027-8424&rft.eissn=1091-6490&rft.coden=PNASA6&rft_id=info:doi/10.1073/pnas.86.11.3978&rft_dat=%3Cjstor_proqu%3E33606%3C/jstor_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=15209009&rft_id=info:pmid/2726761&rft_jstor_id=33606&rfr_iscdi=true |