Identification of vaccine antigens using integrated proteomic analyses of surface immunogens from serogroup B Neisseria meningitidis

Meningococcal surface proteins capable of evoking a protective immune response are candidates for inclusion in protein-based vaccines against serogroup B Neisseria meningitidis (NmB). In this study, a 2-dimensional (2-D) gel-based platform integrating surface and immune-proteomics was developed to c...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of proteomics 2014-04, Vol.101, p.63-76
Hauptverfasser:	Tsolakos, Nikos, Brookes, Charlotte, Taylor, Stephen, Gorringe, Andrew, Tang, Christoph M., Feavers, Ian M., Wheeler, Jun X.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Bacterial - isolation & purification Antigens, Bacterial - metabolism Antigens, Surface - analysis Antigens, Surface - isolation & purification Antigens, Surface - metabolism Bacterial Proteins - immunology Bacterial Proteins - isolation & purification Bacterial Proteins - metabolism Differential gel electrophoresis Endopeptidase K - pharmacology Female Immunoproteome Macrophage infectivity potentiator Meningitis, Meningococcal - immunology Meningococcal vaccines Meningococcal Vaccines - isolation & purification Meningococcal Vaccines - metabolism Mice Mice, Inbred BALB C Neisseria meningitidis Neisseria meningitidis, Serogroup B - chemistry Neisseria meningitidis, Serogroup B - immunology Neisseria meningitidis, Serogroup B - metabolism Proteomics Proteomics - methods
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!