DNA hypermethylation and 1p Loss silence NHE-1 in oligodendroglioma

Oligodendroglioma is characterized by mutations of IDH and CIC, 1p/19q loss, and slow growth. We found that NHE‐1 on 1p is silenced in oligodendrogliomas secondary to IDH‐associated hypermethylation and 1p allelic loss. Silencing lowers intracellular pH and attenuates acid load recovery in oligodend...

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Veröffentlicht in:	Annals of neurology 2012-06, Vol.71 (6), p.845-849
Hauptverfasser:	Blough, Michael D., Al-Najjar, Mohammad, Chesnelong, Charles, Binding, Carmen E., Rogers, Alexandra D., Luchman, H. Artee, Kelly, John J., Fliegel, Larry, Morozova, Olena, Yip, Stephen, Marra, Marco, Weiss, Samuel, Chan, Jennifer A., Cairncross, J. Gregory
Format:	Artikel
Sprache:	eng
Schlagworte:	Brain cancer Brain Neoplasms - genetics Brain Neoplasms - pathology Chromosome Deletion Chromosomes, Human, Pair 1 - genetics Deoxyribonucleic acid DNA DNA Methylation Humans Mutation - genetics Oligodendroglioma - genetics Oligodendroglioma - pathology Protons Sodium Sodium-Hydrogen Exchangers - genetics Tumor Cells, Cultured
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