DNA hypermethylation and 1p Loss silence NHE-1 in oligodendroglioma
Oligodendroglioma is characterized by mutations of IDH and CIC, 1p/19q loss, and slow growth. We found that NHE‐1 on 1p is silenced in oligodendrogliomas secondary to IDH‐associated hypermethylation and 1p allelic loss. Silencing lowers intracellular pH and attenuates acid load recovery in oligodend...
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| Veröffentlicht in: | Annals of neurology 2012-06, Vol.71 (6), p.845-849 |
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| container_title | Annals of neurology |
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| creator | Blough, Michael D. Al-Najjar, Mohammad Chesnelong, Charles Binding, Carmen E. Rogers, Alexandra D. Luchman, H. Artee Kelly, John J. Fliegel, Larry Morozova, Olena Yip, Stephen Marra, Marco Weiss, Samuel Chan, Jennifer A. Cairncross, J. Gregory |
| description | Oligodendroglioma is characterized by mutations of IDH and CIC, 1p/19q loss, and slow growth. We found that NHE‐1 on 1p is silenced in oligodendrogliomas secondary to IDH‐associated hypermethylation and 1p allelic loss. Silencing lowers intracellular pH and attenuates acid load recovery in oligodendroglioma cells. Others have shown that rapid tumor growth cannot occur without NHE‐1–mediated neutralization of the acidosis generated by the Warburg glycolytic shift. Our findings show for the first time that the pH regulator NHE‐1 can be silenced in a human cancer and also suggest that pH deregulation may contribute to the distinctive biology of human oligodendroglioma. Ann Neurol 2012;71:845–849 |
| doi_str_mv | 10.1002/ana.23610 |
| format | Article |
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Our findings show for the first time that the pH regulator NHE‐1 can be silenced in a human cancer and also suggest that pH deregulation may contribute to the distinctive biology of human oligodendroglioma. 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| subjects | Brain cancer Brain Neoplasms - genetics Brain Neoplasms - pathology Chromosome Deletion Chromosomes, Human, Pair 1 - genetics Deoxyribonucleic acid DNA DNA Methylation Humans Mutation - genetics Oligodendroglioma - genetics Oligodendroglioma - pathology Protons Sodium Sodium-Hydrogen Exchangers - genetics Tumor Cells, Cultured |
| title | DNA hypermethylation and 1p Loss silence NHE-1 in oligodendroglioma |
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