Anandamide deficiency and heightened neuropathic pain in aged mice

Damaging of peripheral nerves may result in chronic neuropathic pain for which the likelihood is increased in the elderly. We assessed in mice if age-dependent alterations of endocannabinoids contributed to the heightened vulnerability to neuropathic pain at old age. We assessed nociception, endocan...

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Veröffentlicht in:	Neuropharmacology 2013-08, Vol.71, p.204-215
Hauptverfasser:	Bishay, Philipp, Häussler, Annett, Lim, Hee-Young, Oertel, Bruno, Galve-Roperh, Ismael, Ferreirós, Nerea, Tegeder, Irmgard
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Arachidonoylglycerol Age Aging Amidohydrolases - biosynthesis Amidohydrolases - metabolism Anandamide Animals Arachidonic Acids - deficiency Arachidonic Acids - metabolism Behavior, Animal - drug effects Brain - drug effects Brain - growth & development Brain - metabolism Cannabinoid receptor Cyclooxygenase Cyclooxygenase 1 - biosynthesis Cyclooxygenase 1 - metabolism Cyclooxygenase Inhibitors - blood Cyclooxygenase Inhibitors - pharmacokinetics Cyclooxygenase Inhibitors - therapeutic use Cytochrome P-450 CYP2D6 - biosynthesis Cytochrome P-450 CYP2D6 - metabolism Disease Models, Animal Endocannabinoids Endocannabinoids - deficiency Endocannabinoids - metabolism Enzyme Induction Fatty acid amide hydrolase Flurbiprofen - blood Flurbiprofen - pharmacokinetics Flurbiprofen - therapeutic use Inhibitory control Male Membrane Proteins - biosynthesis Membrane Proteins - metabolism Mice Mice, Inbred C57BL Nerve Tissue Proteins - biosynthesis Nerve Tissue Proteins - metabolism Neuralgia - blood Neuralgia - drug therapy Neuralgia - etiology Neuralgia - metabolism Nociception Pain Peripheral Nerves - drug effects Peripheral Nerves - growth & development Peripheral Nerves - metabolism Polyunsaturated Alkamides - metabolism R-flurbiprofen Spinal Cord - drug effects Spinal Cord - growth & development Spinal Cord - metabolism Stereoisomerism
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