Dose-dependent effect of sulfur dioxide on brain damage induced by recurrent febrile seizures in rats
Sulfur dioxide (SO2) regulates many physiological processes. Little is known about its roles in neurological disorders. In this study, we investigated the role of endogenous SO2 in the development of febrile seizures (FS) and related brain damages. In the rat model of recurrent FS, we found that end...
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| Veröffentlicht in: | Neuroscience letters 2014-03, Vol.563, p.149-154 |
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| creator | Han, Ying Yi, Wenxia Qin, Jiong Zhao, Yang Zhang, Jing Chang, Xingzhi |
| description | Sulfur dioxide (SO2) regulates many physiological processes. Little is known about its roles in neurological disorders. In this study, we investigated the role of endogenous SO2 in the development of febrile seizures (FS) and related brain damages. In the rat model of recurrent FS, we found that endogenous SO2 in the plasma and hippocampus was increased, accompanied by upregulation of aspartate amino-transferase 1 (AAT1) and AAT2, and neuronal apoptosis and mossy fiber sprouting (MFS) in the hippocampus. Preconditioning with low concentration of SO2 (1-10 μmol/kg) alleviated the neuronal damage, and attenuated neuronal apoptosis and MFS, whereas preconditioning with high concentration of SO2 (100 μmol/kg) or inhibition of AAT aggravated the neuronal damage, and promoted neuronal apoptosis and MFS in hippocampus of rats with recurrent FS. These data indicate that endogenous SO2 is involved in the development of FS and related brain damage. Preconditioning with low concentration of SO2 may protect neurons from toxicity caused by FS. |
| doi_str_mv | 10.1016/j.neulet.2013.12.042 |
| format | Article |
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Little is known about its roles in neurological disorders. In this study, we investigated the role of endogenous SO2 in the development of febrile seizures (FS) and related brain damages. In the rat model of recurrent FS, we found that endogenous SO2 in the plasma and hippocampus was increased, accompanied by upregulation of aspartate amino-transferase 1 (AAT1) and AAT2, and neuronal apoptosis and mossy fiber sprouting (MFS) in the hippocampus. Preconditioning with low concentration of SO2 (1-10 μmol/kg) alleviated the neuronal damage, and attenuated neuronal apoptosis and MFS, whereas preconditioning with high concentration of SO2 (100 μmol/kg) or inhibition of AAT aggravated the neuronal damage, and promoted neuronal apoptosis and MFS in hippocampus of rats with recurrent FS. These data indicate that endogenous SO2 is involved in the development of FS and related brain damage. Preconditioning with low concentration of SO2 may protect neurons from toxicity caused by FS.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/j.neulet.2013.12.042</identifier><identifier>PMID: 24373994</identifier><language>eng</language><publisher>Ireland</publisher><subject>Animals ; Apoptosis - drug effects ; Aspartate Aminotransferase, Cytoplasmic - metabolism ; Aspartate Aminotransferase, Mitochondrial - metabolism ; Dose-Response Relationship, Drug ; Hippocampus - drug effects ; Hippocampus - metabolism ; Hippocampus - pathology ; Male ; Neurons - drug effects ; Neurons - metabolism ; Neurons - pathology ; Rats, Sprague-Dawley ; Recurrence ; Seizures, Febrile - metabolism ; Seizures, Febrile - pathology ; Seizures, Febrile - prevention & control ; Sulfur Dioxide - blood ; Sulfur Dioxide - metabolism ; Sulfur Dioxide - pharmacology</subject><ispartof>Neuroscience letters, 2014-03, Vol.563, p.149-154</ispartof><rights>Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c340t-38f754eea159cd1aa08dcdcd573f49279771a91e96aab9721bcdff385c62b6ce3</citedby><cites>FETCH-LOGICAL-c340t-38f754eea159cd1aa08dcdcd573f49279771a91e96aab9721bcdff385c62b6ce3</cites><orcidid>0000-0003-1168-7242</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24373994$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Han, Ying</creatorcontrib><creatorcontrib>Yi, Wenxia</creatorcontrib><creatorcontrib>Qin, Jiong</creatorcontrib><creatorcontrib>Zhao, Yang</creatorcontrib><creatorcontrib>Zhang, Jing</creatorcontrib><creatorcontrib>Chang, Xingzhi</creatorcontrib><title>Dose-dependent effect of sulfur dioxide on brain damage induced by recurrent febrile seizures in rats</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>Sulfur dioxide (SO2) regulates many physiological processes. Little is known about its roles in neurological disorders. In this study, we investigated the role of endogenous SO2 in the development of febrile seizures (FS) and related brain damages. In the rat model of recurrent FS, we found that endogenous SO2 in the plasma and hippocampus was increased, accompanied by upregulation of aspartate amino-transferase 1 (AAT1) and AAT2, and neuronal apoptosis and mossy fiber sprouting (MFS) in the hippocampus. Preconditioning with low concentration of SO2 (1-10 μmol/kg) alleviated the neuronal damage, and attenuated neuronal apoptosis and MFS, whereas preconditioning with high concentration of SO2 (100 μmol/kg) or inhibition of AAT aggravated the neuronal damage, and promoted neuronal apoptosis and MFS in hippocampus of rats with recurrent FS. These data indicate that endogenous SO2 is involved in the development of FS and related brain damage. Preconditioning with low concentration of SO2 may protect neurons from toxicity caused by FS.</description><subject>Animals</subject><subject>Apoptosis - drug effects</subject><subject>Aspartate Aminotransferase, Cytoplasmic - metabolism</subject><subject>Aspartate Aminotransferase, Mitochondrial - metabolism</subject><subject>Dose-Response Relationship, Drug</subject><subject>Hippocampus - drug effects</subject><subject>Hippocampus - metabolism</subject><subject>Hippocampus - pathology</subject><subject>Male</subject><subject>Neurons - drug effects</subject><subject>Neurons - metabolism</subject><subject>Neurons - pathology</subject><subject>Rats, Sprague-Dawley</subject><subject>Recurrence</subject><subject>Seizures, Febrile - metabolism</subject><subject>Seizures, Febrile - pathology</subject><subject>Seizures, Febrile - prevention & control</subject><subject>Sulfur Dioxide - blood</subject><subject>Sulfur Dioxide - metabolism</subject><subject>Sulfur Dioxide - pharmacology</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kMtOwzAQRS0EoqXwBwh5ySbBYzsPL1F5SpXYwNpy7DFKlSbFjiXK15OqBc1iNvfM6B5CroHlwKC8W-c9pg7HnDMQOfCcSX5C5lBXPKtUxU_JnAkmM6Ekm5GLGNeMsQIKeU5mXIpKKCXnBB-GiJnDLfYO-5Gi92hHOngaU-dToK4dvluHdOhpE0zbU2c25hNp27tk0dFmRwPaFMKe9tiEtkMasf1JAeOUosGM8ZKcedNFvDruBfl4enxfvmSrt-fX5f0qs0KyMRO1rwqJaKBQ1oExrHZ2mqISXio-tarAKEBVGtNMFaGxzntRF7bkTWlRLMjt4e42DF8J46g3bbTYdabHIUUNBWeiVgLYFJWHqA1DjAG93oZ2Y8JOA9N7wXqtD4L1XrAGrifBE3Zz_JCaDbp_6M-o-AVBkXq3</recordid><startdate>20140320</startdate><enddate>20140320</enddate><creator>Han, Ying</creator><creator>Yi, Wenxia</creator><creator>Qin, Jiong</creator><creator>Zhao, Yang</creator><creator>Zhang, Jing</creator><creator>Chang, Xingzhi</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope><orcidid>https://orcid.org/0000-0003-1168-7242</orcidid></search><sort><creationdate>20140320</creationdate><title>Dose-dependent effect of sulfur dioxide on brain damage induced by recurrent febrile seizures in rats</title><author>Han, Ying ; Yi, Wenxia ; Qin, Jiong ; Zhao, Yang ; Zhang, Jing ; Chang, Xingzhi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c340t-38f754eea159cd1aa08dcdcd573f49279771a91e96aab9721bcdff385c62b6ce3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Animals</topic><topic>Apoptosis - drug effects</topic><topic>Aspartate Aminotransferase, Cytoplasmic - metabolism</topic><topic>Aspartate Aminotransferase, Mitochondrial - metabolism</topic><topic>Dose-Response Relationship, Drug</topic><topic>Hippocampus - drug effects</topic><topic>Hippocampus - metabolism</topic><topic>Hippocampus - pathology</topic><topic>Male</topic><topic>Neurons - drug effects</topic><topic>Neurons - metabolism</topic><topic>Neurons - pathology</topic><topic>Rats, Sprague-Dawley</topic><topic>Recurrence</topic><topic>Seizures, Febrile - metabolism</topic><topic>Seizures, Febrile - pathology</topic><topic>Seizures, Febrile - prevention & control</topic><topic>Sulfur Dioxide - blood</topic><topic>Sulfur Dioxide - metabolism</topic><topic>Sulfur Dioxide - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Han, Ying</creatorcontrib><creatorcontrib>Yi, Wenxia</creatorcontrib><creatorcontrib>Qin, Jiong</creatorcontrib><creatorcontrib>Zhao, Yang</creatorcontrib><creatorcontrib>Zhang, Jing</creatorcontrib><creatorcontrib>Chang, Xingzhi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Han, Ying</au><au>Yi, Wenxia</au><au>Qin, Jiong</au><au>Zhao, Yang</au><au>Zhang, Jing</au><au>Chang, Xingzhi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dose-dependent effect of sulfur dioxide on brain damage induced by recurrent febrile seizures in rats</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>2014-03-20</date><risdate>2014</risdate><volume>563</volume><spage>149</spage><epage>154</epage><pages>149-154</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><abstract>Sulfur dioxide (SO2) regulates many physiological processes. Little is known about its roles in neurological disorders. In this study, we investigated the role of endogenous SO2 in the development of febrile seizures (FS) and related brain damages. In the rat model of recurrent FS, we found that endogenous SO2 in the plasma and hippocampus was increased, accompanied by upregulation of aspartate amino-transferase 1 (AAT1) and AAT2, and neuronal apoptosis and mossy fiber sprouting (MFS) in the hippocampus. Preconditioning with low concentration of SO2 (1-10 μmol/kg) alleviated the neuronal damage, and attenuated neuronal apoptosis and MFS, whereas preconditioning with high concentration of SO2 (100 μmol/kg) or inhibition of AAT aggravated the neuronal damage, and promoted neuronal apoptosis and MFS in hippocampus of rats with recurrent FS. These data indicate that endogenous SO2 is involved in the development of FS and related brain damage. Preconditioning with low concentration of SO2 may protect neurons from toxicity caused by FS.</abstract><cop>Ireland</cop><pmid>24373994</pmid><doi>10.1016/j.neulet.2013.12.042</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0003-1168-7242</orcidid></addata></record> |
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| ispartof | Neuroscience letters, 2014-03, Vol.563, p.149-154 |
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| language | eng |
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| subjects | Animals Apoptosis - drug effects Aspartate Aminotransferase, Cytoplasmic - metabolism Aspartate Aminotransferase, Mitochondrial - metabolism Dose-Response Relationship, Drug Hippocampus - drug effects Hippocampus - metabolism Hippocampus - pathology Male Neurons - drug effects Neurons - metabolism Neurons - pathology Rats, Sprague-Dawley Recurrence Seizures, Febrile - metabolism Seizures, Febrile - pathology Seizures, Febrile - prevention & control Sulfur Dioxide - blood Sulfur Dioxide - metabolism Sulfur Dioxide - pharmacology |
| title | Dose-dependent effect of sulfur dioxide on brain damage induced by recurrent febrile seizures in rats |
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