The abilities of selenium dioxide and selenite ion to coordinate DNA-bound metal ions and decrease oxidative DNA damage

Several transition metals react with H2O2 and produce reactive oxygen species (ROS) responsible for oxidative damage linked to many diseases and disorders, and species that form coordination complexes with these metal ions show promise as antioxidants. The present study demonstrates that metal-media...

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Veröffentlicht in:	Journal of inorganic biochemistry 2013-08, Vol.125, p.1-8
Hauptverfasser:	Hart, William E., Marczak, Steven P., Kneller, Andrew R., French, Robert A., Morris, Daniel L.
Format:	Artikel
Sprache:	eng
Schlagworte:	8-hydroxy-2′-deoxyguanosine Antioxidant Antioxidants - chemistry Antioxidants - metabolism Binding Sites Chromium - chemistry Chromium - metabolism Copper - chemistry Copper - metabolism Deoxyguanosine - analogs & derivatives Deoxyguanosine - chemistry Deoxyguanosine - metabolism DNA - metabolism DNA Damage Hydrogen Peroxide - chemistry Hydrogen Peroxide - metabolism Inorganic selenium compounds Ions Oxidation-Reduction Oxidative DNA damage Reactive Oxygen Species - metabolism Selenious Acid - chemistry Selenious Acid - metabolism Selenium Oxides - chemistry Selenium Oxides - metabolism
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