Schiff’s base derivatives bearing nitroimidazole and quinoline nuclei: New class of anticancer agents and potential EGFR tyrosine kinase inhibitors

New Schiff’s base derivatives 5a–j have been synthesized by reaction between 2-phenoxyquinoline-3-carbaldehydes and 2-(2-methyl-5-nitro-1H-imidazol-1-yl)acetohydrazide in presence of nickel(II) nitrate as a catalyst in ethanol under reflux in good yield (78–92%). All compounds were tested for antica...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2014-04, Vol.24 (7), p.1734-1736
Hauptverfasser:	Makawana, Jigar A., Sangani, Chetan B., Lin, Lin, Zhu, Hai-Liang
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticancer activity Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Cell Line, Tumor Cell Proliferation - drug effects Dose-Response Relationship, Drug Drug Screening Assays, Antitumor EGFR inhibition Hep G2 Cells Humans Molecular Docking Simulation Molecular Structure Nitroimidazole Nitroimidazoles - chemistry Protein Kinase Inhibitors - chemical synthesis Protein Kinase Inhibitors - chemistry Protein Kinase Inhibitors - pharmacology Quinoline Quinolines - chemistry Receptor, Epidermal Growth Factor - antagonists & inhibitors Receptor, Epidermal Growth Factor - metabolism Schiff Bases - chemical synthesis Schiff Bases - chemistry Schiff Bases - pharmacology Schiff’s base Structure-Activity Relationship
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