Synthesis and antibacterial activity of a series of novel 9-O-acetyl- 4′-substituted 16-membered macrolides derived from josamycin

A series of novel 9-O-acetyl-4′-substituted 16-membered macrolides derived from josamycin were synthesized and evaluated for their antibacterial activities. A series of novel 9-O-acetyl-4′-substituted 16-membered macrolides derived from josamycin has been designed and synthesized by cleavage of the...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2014-01, Vol.24 (2), p.480-484
Hauptverfasser:	Zhao, Zhehui, Jin, Longlong, Xu, Yanpeng, Zhu, Di, Liu, Yi, Liu, Chao, Lei, Pingsheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - pharmacology Antibacterial activity Crystallography, X-Ray Josamycin Josamycin - analogs & derivatives Josamycin - chemical synthesis Josamycin - pharmacology Macrolide Macrolides - chemical synthesis Macrolides - pharmacology Microbial Sensitivity Tests - methods Staphylococcus aureus Staphylococcus aureus - drug effects Staphylococcus aureus - physiology Staphylococcus epidermidis Staphylococcus epidermidis - drug effects Staphylococcus epidermidis - physiology Synthesis
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