Proteomic analysis of human substantia nigra identifies novel candidates involved in Parkinson's disease pathogenesis

Parkinson's disease (PD) pathology spreads throughout the brain following a region‐specific process predominantly affecting the substantia nigra (SN) pars compacta. SN exhibits a progressive loss of dopaminergic neurons responsible for the major cardinal motor symptoms, along with the occurrenc...

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Veröffentlicht in:	Proteomics (Weinheim) 2014-03, Vol.14 (6), p.784-794
Hauptverfasser:	Licker, Virginie, Turck, Natacha, Kövari, Enikö, Burkhardt, Karim, Côte, Mélanie, Surini-Demiri, Maria, Lobrinus, Johannes A., Sanchez, Jean-Charles, Burkhard, Pierre R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Biomedicine Female Humans Male Middle Aged Nebulette Parkinson Disease - diagnosis Parkinson Disease - metabolism Parkinson Disease - pathology Parkinson's disease Postmortem tissue Proteome - analysis Proteome - metabolism Proteomics - methods Substantia nigra Substantia Nigra - metabolism Substantia Nigra - pathology
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