Synthesis and antifungal activity of diverse C-2 pyridinyl and pyridinylvinyl substituted quinolines

Diverse 2-pyridinyl quinolines 6–12 and 2-pyridinilvinyl quinolines 13–17 were prepared using a straightforward synthesis based on the BiCl3-catalyzed multicomponent imino Diels–Alder (imino DA) reaction or a novel tandem imino DA/catalytic tetrahydroquinoline ring oxidation/Perkin condensation sequ...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2012-11, Vol.20 (21), p.6506-6512
Hauptverfasser:	Kouznetsov, Vladimir V., Meléndez Gómez, Carlos M., Derita, Marcos G., Svetaz, Laura, del Olmo, Esther, Zacchino, Susana A.
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Pyridinyl and 2-pyridinylvinyl quinoline derivatives Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal agents Antifungal Agents - chemical synthesis Antifungal Agents - chemistry Antifungal Agents - pharmacology antifungal properties Biological and medical sciences Candida albicans Candida albicans - drug effects condensation Cryptococcus neoformans Cryptococcus neoformans - drug effects Diversity-oriented synthesis Dose-Response Relationship, Drug Imino Diels–Alder reaction keratinophilic fungi Medical sciences Microbial Sensitivity Tests Molecular Structure oxidation Pharmacology. Drug treatments Pyridines - chemistry quinoline Quinolines - chemical synthesis Quinolines - chemistry Quinolines - pharmacology Structure-Activity Relationship
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