Neuroinflammation: the role and consequences

Neuroinflammation: the role and consequences

Neuroinflammation is central to the common pathology of several acute and chronic brain diseases. This review examines the consequences of excessive and prolonged neuroinflammation, particularly its damaging effects on cellular and/or brain function, as well as its relevance to disease progression a...

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Veröffentlicht in:Neuroscience research 2014-02, Vol.79, p.1-12
Hauptverfasser: Lyman, Monty, Lloyd, Dafydd G, Ji, Xunming, Vizcaychipi, Marcela P, Ma, Daqing
Format: Artikel
Sprache:eng
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Encephalitis - complications
Encephalitis - metabolism
Encephalitis - physiopathology
Humans
Neurodegenerative Diseases - etiology
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container_title Neuroscience research
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creator Lyman, Monty
Lloyd, Dafydd G
Ji, Xunming
Vizcaychipi, Marcela P
Ma, Daqing
description Neuroinflammation is central to the common pathology of several acute and chronic brain diseases. This review examines the consequences of excessive and prolonged neuroinflammation, particularly its damaging effects on cellular and/or brain function, as well as its relevance to disease progression and possible interventions. The evidence gathered here indicates that neuroinflammation causes and accelerates long-term neurodegenerative disease, playing a central role in the very early development of chronic conditions including dementia. The wide scope and numerous complexities of neuroinflammation suggest that combinations of different preventative and therapeutic approaches may be efficacious.
doi_str_mv 10.1016/j.neures.2013.10.004
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subjects Encephalitis - complications
Encephalitis - metabolism
Encephalitis - physiopathology
Humans
Neurodegenerative Diseases - etiology
title Neuroinflammation: the role and consequences
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