L233P mutation of the Tax protein strongly correlated with leukemogenicity of bovine leukemia virus

The bovine leukemia virus (BLV) Tax protein is believed to play a crucial role in leukemogenesis by the virus. BLV usually causes asymptomatic infections in cattle, but only one-third develop persistent lymphocytosis that rarely progress after a long incubation period to lymphoid tumors, namely enzo...

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Veröffentlicht in:	Veterinary microbiology 2013-12, Vol.167 (3-4), p.364-371
Hauptverfasser:	Inoue, Emi, Matsumura, Keiko, Soma, Norihiko, Hirasawa, Shintaro, Wakimoto, Mayuko, Arakaki, Yoshihiro, Yoshida, Takashi, Osawa, Yoshiaki, Okazaki, Katsunori
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Distribution Alleles Animals Bovine leukemia virus Cattle cattle breeding Enzootic bovine leucosis Enzootic Bovine Leukosis - virology Female Gene Expression Regulation, Viral Gene Products, tax - genetics Genetic Variation incubation period Japan Leukemia Virus, Bovine - genetics Leukemia Virus, Bovine - pathogenicity Leukemogenicity Mutation Mutation - genetics neoplasms parturition Phylogeny Polymerase Chain Reaction proteins Tax protein viruses
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