Case–control risk factor study of methicillin-resistant Staphylococcus pseudintermedius (MRSP) infection in dogs and cats in Germany
Methicillin-resistant Staphylococcus pseudintermedius (MRSP) has emerged as a highly drug-resistant small animal veterinary pathogen. Although often isolated from outpatients in veterinary clinics, there is concern that MRSP follows a veterinary-hospital-associated epidemiology. This study's ob...
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| Veröffentlicht in: | Veterinary microbiology 2014-01, Vol.168 (1), p.154-160 |
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| creator | Lehner, Georg Linek, Monika Bond, Ross Lloyd, David H. Prenger-Berninghoff, Ellen Thom, Nina Straube, Iris Verheyen, Kristien Loeffler, Anette |
| description | Methicillin-resistant Staphylococcus pseudintermedius (MRSP) has emerged as a highly drug-resistant small animal veterinary pathogen. Although often isolated from outpatients in veterinary clinics, there is concern that MRSP follows a veterinary-hospital-associated epidemiology. This study's objective was to identify risk factors for MRSP infections in dogs and cats in Germany. Clinical isolates of MRSP cases (n=150) and methicillin-susceptible S. pseudintermedius (MSSP) controls (n=133) and their corresponding host signalment and medical data covering the six months prior to staphylococcal isolation were analysed by multivariable logistic regression. The identity of all MRSP isolates was confirmed through demonstration of S. intermedius-group specific nuc and mecA. In the final model, cats (compared to dogs, OR 18.5, 95% CI 1.8–188.0, P=0.01), animals that had been hospitalised (OR 104.4, 95% CI 21.3–511.6, P10 visits OR 7.3, 95% CI 1.0–52.6, P=0.049) and those that had received topical ear medication (OR 5.1, 95% CI 1.8–14.9, P=0.003) or glucocorticoids (OR 22.5, 95% CI 7.0–72.6, P |
| doi_str_mv | 10.1016/j.vetmic.2013.10.023 |
| format | Article |
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Although often isolated from outpatients in veterinary clinics, there is concern that MRSP follows a veterinary-hospital-associated epidemiology. This study's objective was to identify risk factors for MRSP infections in dogs and cats in Germany. Clinical isolates of MRSP cases (n=150) and methicillin-susceptible S. pseudintermedius (MSSP) controls (n=133) and their corresponding host signalment and medical data covering the six months prior to staphylococcal isolation were analysed by multivariable logistic regression. The identity of all MRSP isolates was confirmed through demonstration of S. intermedius-group specific nuc and mecA. In the final model, cats (compared to dogs, OR 18.5, 95% CI 1.8–188.0, P=0.01), animals that had been hospitalised (OR 104.4, 95% CI 21.3–511.6, P<0.001), or visited veterinary clinics more frequently (>10 visits OR 7.3, 95% CI 1.0–52.6, P=0.049) and those that had received topical ear medication (OR 5.1, 95% CI 1.8–14.9, P=0.003) or glucocorticoids (OR 22.5, 95% CI 7.0–72.6, P<0.001) were at higher risk of MRSP infection, whereas S. pseudintermedius isolates from ears were more likely to belong to the MSSP-group (OR 0.09, 95% CI 0.03–0.34, P<0.001). These results indicate an association of MRSP infection with veterinary clinic/hospital settings and possibly with chronic skin disease. There was an unexpected lack of association between MRSP and antimicrobial therapy; this requires further investigation but may indicate that MRSP is well adapted to canine skin with little need for selective pressure.</description><identifier>ISSN: 0378-1135</identifier><identifier>EISSN: 1873-2542</identifier><identifier>DOI: 10.1016/j.vetmic.2013.10.023</identifier><identifier>PMID: 24290489</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Animals ; Anti-Bacterial Agents - therapeutic use ; Antimicrobial resistance ; Bacterial Proteins - genetics ; Case-Control Studies ; Cat Diseases - drug therapy ; Cat Diseases - epidemiology ; Cat Diseases - microbiology ; Cats ; Dog Diseases - drug therapy ; Dog Diseases - epidemiology ; Dog Diseases - microbiology ; Dogs ; Female ; Germany - epidemiology ; Hospitals, Animal - statistics & numerical data ; Infection control ; Male ; Methicillin Resistance - genetics ; Micrococcal Nuclease - genetics ; Models, Biological ; MRSP ; Otitis ; Pyoderma ; Risk Factors ; Staphylococcal Infections - drug therapy ; Staphylococcal Infections - epidemiology ; Staphylococcal Infections - microbiology ; Staphylococcal Infections - veterinary ; Staphylococcus ; Staphylococcus - drug effects ; Staphylococcus - genetics ; Veterinary</subject><ispartof>Veterinary microbiology, 2014-01, Vol.168 (1), p.154-160</ispartof><rights>2013 Elsevier B.V.</rights><rights>Copyright © 2013 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c361t-c1cd8b02f3269e0e22e59f0b3cdbe7a8310a73a910b9a24cacc30d6a679f90cf3</citedby><cites>FETCH-LOGICAL-c361t-c1cd8b02f3269e0e22e59f0b3cdbe7a8310a73a910b9a24cacc30d6a679f90cf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.vetmic.2013.10.023$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3541,27915,27916,45986</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24290489$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lehner, Georg</creatorcontrib><creatorcontrib>Linek, Monika</creatorcontrib><creatorcontrib>Bond, Ross</creatorcontrib><creatorcontrib>Lloyd, David H.</creatorcontrib><creatorcontrib>Prenger-Berninghoff, Ellen</creatorcontrib><creatorcontrib>Thom, Nina</creatorcontrib><creatorcontrib>Straube, Iris</creatorcontrib><creatorcontrib>Verheyen, Kristien</creatorcontrib><creatorcontrib>Loeffler, Anette</creatorcontrib><title>Case–control risk factor study of methicillin-resistant Staphylococcus pseudintermedius (MRSP) infection in dogs and cats in Germany</title><title>Veterinary microbiology</title><addtitle>Vet Microbiol</addtitle><description>Methicillin-resistant Staphylococcus pseudintermedius (MRSP) has emerged as a highly drug-resistant small animal veterinary pathogen. Although often isolated from outpatients in veterinary clinics, there is concern that MRSP follows a veterinary-hospital-associated epidemiology. This study's objective was to identify risk factors for MRSP infections in dogs and cats in Germany. Clinical isolates of MRSP cases (n=150) and methicillin-susceptible S. pseudintermedius (MSSP) controls (n=133) and their corresponding host signalment and medical data covering the six months prior to staphylococcal isolation were analysed by multivariable logistic regression. The identity of all MRSP isolates was confirmed through demonstration of S. intermedius-group specific nuc and mecA. In the final model, cats (compared to dogs, OR 18.5, 95% CI 1.8–188.0, P=0.01), animals that had been hospitalised (OR 104.4, 95% CI 21.3–511.6, P<0.001), or visited veterinary clinics more frequently (>10 visits OR 7.3, 95% CI 1.0–52.6, P=0.049) and those that had received topical ear medication (OR 5.1, 95% CI 1.8–14.9, P=0.003) or glucocorticoids (OR 22.5, 95% CI 7.0–72.6, P<0.001) were at higher risk of MRSP infection, whereas S. pseudintermedius isolates from ears were more likely to belong to the MSSP-group (OR 0.09, 95% CI 0.03–0.34, P<0.001). These results indicate an association of MRSP infection with veterinary clinic/hospital settings and possibly with chronic skin disease. There was an unexpected lack of association between MRSP and antimicrobial therapy; this requires further investigation but may indicate that MRSP is well adapted to canine skin with little need for selective pressure.</description><subject>Animals</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Antimicrobial resistance</subject><subject>Bacterial Proteins - genetics</subject><subject>Case-Control Studies</subject><subject>Cat Diseases - drug therapy</subject><subject>Cat Diseases - epidemiology</subject><subject>Cat Diseases - microbiology</subject><subject>Cats</subject><subject>Dog Diseases - drug therapy</subject><subject>Dog Diseases - epidemiology</subject><subject>Dog Diseases - microbiology</subject><subject>Dogs</subject><subject>Female</subject><subject>Germany - epidemiology</subject><subject>Hospitals, Animal - statistics & numerical data</subject><subject>Infection control</subject><subject>Male</subject><subject>Methicillin Resistance - genetics</subject><subject>Micrococcal Nuclease - genetics</subject><subject>Models, Biological</subject><subject>MRSP</subject><subject>Otitis</subject><subject>Pyoderma</subject><subject>Risk Factors</subject><subject>Staphylococcal Infections - drug therapy</subject><subject>Staphylococcal Infections - epidemiology</subject><subject>Staphylococcal Infections - microbiology</subject><subject>Staphylococcal Infections - veterinary</subject><subject>Staphylococcus</subject><subject>Staphylococcus - drug effects</subject><subject>Staphylococcus - genetics</subject><subject>Veterinary</subject><issn>0378-1135</issn><issn>1873-2542</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcFu1DAQhi0EotvCGyDkYzlkGdvZJL4goRUUpCIQhbPlTCbUS2IvtlNpb5z6ArwhT0LCFo5wmtGv75-R_p-xJwLWAkT1fLe-oTw6XEsQapbWINU9thJNrQq5KeV9tgJVN4UQanPCTlPaAUCpK3jITmQpNZSNXrHbrU308_sPDD7HMPDo0lfeW8wh8pSn7sBDz0fK1w7dMDhfREouZeszv8p2f30YAgbEKfF9oqlzPlMcqXOzcP7u49WHZ9z5njC74OeNd-FL4tZ3HG1Oi3Ax49YfHrEHvR0SPb6bZ-zz61eftm-Ky_cXb7cvLwtUlcgFCuyaFmSvZKUJSEra6B5ahV1LtW2UAFsrqwW02soSLaKCrrJVrXsN2Kszdn68u4_h20Qpm9ElpGGwnsKUjNhIUI1shPo_WmqoG1XKBS2PKMaQUqTe7KMbbTwYAWYpy-zMsSyzlLWo8Nv29O7D1M6Z_TX9aWcGXhwBmiO5cRRNQkce53zjnKnpgvv3h18z5asA</recordid><startdate>20140110</startdate><enddate>20140110</enddate><creator>Lehner, Georg</creator><creator>Linek, Monika</creator><creator>Bond, Ross</creator><creator>Lloyd, David H.</creator><creator>Prenger-Berninghoff, Ellen</creator><creator>Thom, Nina</creator><creator>Straube, Iris</creator><creator>Verheyen, Kristien</creator><creator>Loeffler, Anette</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QL</scope><scope>C1K</scope></search><sort><creationdate>20140110</creationdate><title>Case–control risk factor study of methicillin-resistant Staphylococcus pseudintermedius (MRSP) infection in dogs and cats in Germany</title><author>Lehner, Georg ; Linek, Monika ; Bond, Ross ; Lloyd, David H. ; Prenger-Berninghoff, Ellen ; Thom, Nina ; Straube, Iris ; Verheyen, Kristien ; Loeffler, Anette</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c361t-c1cd8b02f3269e0e22e59f0b3cdbe7a8310a73a910b9a24cacc30d6a679f90cf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Animals</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Antimicrobial resistance</topic><topic>Bacterial Proteins - genetics</topic><topic>Case-Control Studies</topic><topic>Cat Diseases - drug therapy</topic><topic>Cat Diseases - epidemiology</topic><topic>Cat Diseases - microbiology</topic><topic>Cats</topic><topic>Dog Diseases - drug therapy</topic><topic>Dog Diseases - epidemiology</topic><topic>Dog Diseases - microbiology</topic><topic>Dogs</topic><topic>Female</topic><topic>Germany - epidemiology</topic><topic>Hospitals, Animal - statistics & numerical data</topic><topic>Infection control</topic><topic>Male</topic><topic>Methicillin Resistance - genetics</topic><topic>Micrococcal Nuclease - genetics</topic><topic>Models, Biological</topic><topic>MRSP</topic><topic>Otitis</topic><topic>Pyoderma</topic><topic>Risk Factors</topic><topic>Staphylococcal Infections - drug therapy</topic><topic>Staphylococcal Infections - epidemiology</topic><topic>Staphylococcal Infections - microbiology</topic><topic>Staphylococcal Infections - veterinary</topic><topic>Staphylococcus</topic><topic>Staphylococcus - drug effects</topic><topic>Staphylococcus - genetics</topic><topic>Veterinary</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lehner, Georg</creatorcontrib><creatorcontrib>Linek, Monika</creatorcontrib><creatorcontrib>Bond, Ross</creatorcontrib><creatorcontrib>Lloyd, David H.</creatorcontrib><creatorcontrib>Prenger-Berninghoff, Ellen</creatorcontrib><creatorcontrib>Thom, Nina</creatorcontrib><creatorcontrib>Straube, Iris</creatorcontrib><creatorcontrib>Verheyen, Kristien</creatorcontrib><creatorcontrib>Loeffler, Anette</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Veterinary microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lehner, Georg</au><au>Linek, Monika</au><au>Bond, Ross</au><au>Lloyd, David H.</au><au>Prenger-Berninghoff, Ellen</au><au>Thom, Nina</au><au>Straube, Iris</au><au>Verheyen, Kristien</au><au>Loeffler, Anette</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Case–control risk factor study of methicillin-resistant Staphylococcus pseudintermedius (MRSP) infection in dogs and cats in Germany</atitle><jtitle>Veterinary microbiology</jtitle><addtitle>Vet Microbiol</addtitle><date>2014-01-10</date><risdate>2014</risdate><volume>168</volume><issue>1</issue><spage>154</spage><epage>160</epage><pages>154-160</pages><issn>0378-1135</issn><eissn>1873-2542</eissn><abstract>Methicillin-resistant Staphylococcus pseudintermedius (MRSP) has emerged as a highly drug-resistant small animal veterinary pathogen. Although often isolated from outpatients in veterinary clinics, there is concern that MRSP follows a veterinary-hospital-associated epidemiology. This study's objective was to identify risk factors for MRSP infections in dogs and cats in Germany. Clinical isolates of MRSP cases (n=150) and methicillin-susceptible S. pseudintermedius (MSSP) controls (n=133) and their corresponding host signalment and medical data covering the six months prior to staphylococcal isolation were analysed by multivariable logistic regression. The identity of all MRSP isolates was confirmed through demonstration of S. intermedius-group specific nuc and mecA. In the final model, cats (compared to dogs, OR 18.5, 95% CI 1.8–188.0, P=0.01), animals that had been hospitalised (OR 104.4, 95% CI 21.3–511.6, P<0.001), or visited veterinary clinics more frequently (>10 visits OR 7.3, 95% CI 1.0–52.6, P=0.049) and those that had received topical ear medication (OR 5.1, 95% CI 1.8–14.9, P=0.003) or glucocorticoids (OR 22.5, 95% CI 7.0–72.6, P<0.001) were at higher risk of MRSP infection, whereas S. pseudintermedius isolates from ears were more likely to belong to the MSSP-group (OR 0.09, 95% CI 0.03–0.34, P<0.001). These results indicate an association of MRSP infection with veterinary clinic/hospital settings and possibly with chronic skin disease. There was an unexpected lack of association between MRSP and antimicrobial therapy; this requires further investigation but may indicate that MRSP is well adapted to canine skin with little need for selective pressure.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>24290489</pmid><doi>10.1016/j.vetmic.2013.10.023</doi><tpages>7</tpages></addata></record> |
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| subjects | Animals Anti-Bacterial Agents - therapeutic use Antimicrobial resistance Bacterial Proteins - genetics Case-Control Studies Cat Diseases - drug therapy Cat Diseases - epidemiology Cat Diseases - microbiology Cats Dog Diseases - drug therapy Dog Diseases - epidemiology Dog Diseases - microbiology Dogs Female Germany - epidemiology Hospitals, Animal - statistics & numerical data Infection control Male Methicillin Resistance - genetics Micrococcal Nuclease - genetics Models, Biological MRSP Otitis Pyoderma Risk Factors Staphylococcal Infections - drug therapy Staphylococcal Infections - epidemiology Staphylococcal Infections - microbiology Staphylococcal Infections - veterinary Staphylococcus Staphylococcus - drug effects Staphylococcus - genetics Veterinary |
| title | Case–control risk factor study of methicillin-resistant Staphylococcus pseudintermedius (MRSP) infection in dogs and cats in Germany |
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