PEGylation of HPMA-based block copolymers enhances tumor accumulation in vivo: A quantitative study using radiolabeling and positron emission tomography

This paper reports the body distribution of block copolymers (made by controlled radical polymerization) with N-(2-hydroxypropyl)methacrylamide (HPMA) as hydrophilic block and lauryl methacrylate (LMA) as hydrophobic block. They form micellar aggregates in aqueous solution. For this study the hydrop...

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Veröffentlicht in:	Journal of controlled release 2013-11, Vol.172 (1), p.77-85
Hauptverfasser:	Allmeroth, Mareli, Moderegger, Dorothea, Gündel, Daniel, Buchholz, Hans-Georg, Mohr, Nicole, Koynov, Kaloian, Rösch, Frank, Thews, Oliver, Zentel, Rudolf
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals aqueous solutions blood blood circulation carcinoma chemical bonding composite polymers drug carriers ethylene glycol Fluorine Radioisotopes - chemistry Fluorine Radioisotopes - pharmacokinetics Fluorine-18 labeling HPMA hydrophilicity hydrophobicity liver Male Mammary Neoplasms, Animal - diagnosis Mammary Neoplasms, Animal - diagnostic imaging Methacrylates - chemistry Methacrylates - pharmacokinetics Micelles PEG PET Polyethylene Glycols - chemistry Polyethylene Glycols - pharmacokinetics polymerization Positron-Emission Tomography radiolabeling Rats Rats, Sprague-Dawley renal clearance spleen Structure–property relationships Tissue Distribution Walker 256 mammary carcinoma
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