The APP intracellular domain (AICD) potentiates ER stress-induced apoptosis

Abstract Here we employed human SHEP neuroblastoma cells either stably or inducibly expressing the amyloid precursor protein (APP) intracellular domain (AICD) to investigate its ability to modulate stress-induced cell death. Analysis of effector caspase activation revealed that AICD overexpression w...

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Veröffentlicht in:	Neurobiology of aging 2012-09, Vol.33 (9), p.2200-2209
Hauptverfasser:	Kögel, Donat, Concannon, Caoimhín G, Müller, Thorsten, König, Hildegard, Bonner, Caroline, Poeschel, Simone, Chang, Steffi, Egensperger, Rupert, Prehn, Jochen H.M
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Amyloid precursor protein Apoptosis Apoptosis - drug effects Caspases Cell Line, Tumor Clusterin - genetics Clusterin - metabolism Cytidine Deaminase - pharmacology Dose-Response Relationship, Drug Drug Interactions Endoplasmic Reticulum Stress - drug effects Endoplasmic Reticulum Stress - physiology Enzyme Inhibitors - pharmacology ER stress Flow Cytometry Gene Expression Regulation - drug effects Green Fluorescent Proteins - genetics Heat-Shock Proteins - genetics Heat-Shock Proteins - metabolism Humans Internal Medicine Neuroblastoma Neurology RNA, Messenger - metabolism Signal Transduction - drug effects Thapsigargin - pharmacology Time Factors Transcription Transfection Tunicamycin - pharmacology Unfolded protein response Unfolded Protein Response - drug effects
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