Immunoneuropathogenesis of HIV-1 clades B and C: role of redox expression and thiol modification

Previous studies have shown that, during infection, HIV-1 clade B and clade C differentially contribute to the neuropathogenesis and development of HIV-associated neurocognitive disorders (HANDs). The low-molecular-weight tripeptide glutathione (GSH) alters the redox balance and leads to the generat...

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Veröffentlicht in:	Free radical biology & medicine 2014-04, Vol.69, p.136-144
Hauptverfasser:	Samikkannu, Thangavel, Rao, Kurapati V K, Kanthikeel, Sudhessh Pilakka, Atluri, Venkata Subba Rao, Agudelo, Marisela, Roy, Upal, Nair, Madhavan P N
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS Dementia Complex - metabolism AIDS Dementia Complex - pathology AIDS Dementia Complex - virology Astrocytes - metabolism Astrocytes - pathology Dendritic Cells - pathology Glutathione - metabolism HIV-1 - genetics HIV-1 - metabolism HIV-1 - pathogenicity Human immunodeficiency virus 1 Humans Oxidation-Reduction Reactive Oxygen Species - metabolism Sulfhydryl Compounds - administration & dosage Superoxide Dismutase - metabolism Superoxide Dismutase-1
Online-Zugang:	Volltext
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