5-Lipoxygenase gene transfer worsens memory, amyloid, and tau brain pathologies in a mouse model of alzheimer disease

Objective: The 5‐lipoxygenase (5LO) enzyme is upregulated in Alzheimer disease (AD), and its genetic absence reduces Aβ levels in APP mice. However, its functional role in modulating tau neuropathology remains to be elucidated. Methods: To this end, we generated triple transgenic mice (3xTg‐AD) over...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Annals of neurology 2012-09, Vol.72 (3), p.442-454
Hauptverfasser:	Chu, Jin, Giannopoulos, Phillip F., Ceballos-Diaz, Carolina, Golde, Todd E., Praticò, Domenico
Format:	Artikel
Sprache:	eng
Schlagworte:	ADAM Proteins - metabolism ADAM10 Protein Alzheimer Disease - complications Alzheimer Disease - genetics Alzheimer Disease - pathology Amyloid beta-Peptides - genetics Amyloid beta-Peptides - metabolism Amyloid beta-Protein Precursor - genetics Amyloid Precursor Protein Secretases - metabolism Animals Arachidonate 5-Lipoxygenase - metabolism Aspartic Acid Endopeptidases - metabolism Biological and medical sciences Brain - metabolism Cells, Cultured Cyclin-Dependent Kinase 5 - metabolism Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Disease Models, Animal Enzyme-Linked Immunosorbent Assay Gene Expression Regulation - genetics Gene Expression Regulation - physiology Humans Maze Learning Medical research Medical sciences Membrane Proteins - metabolism Memory Disorders - etiology Memory Disorders - metabolism Memory Disorders - pathology Mice Mice, Transgenic Neurology NFI Transcription Factors - metabolism Peptide Fragments - metabolism Phosphorylation - genetics Presenilin-1 - genetics Radioimmunoassay Random Allocation Rodents Signal Transduction - genetics tau Proteins - metabolism Transfection
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!