In vitro exposure of human blood mononuclear cells to active vitamin D does not induce substantial change to DNA methylation on a genome-scale

•Human blood mononuclear cells were stimulated with calcitriol for up to 120h.•We observed no substantial changes to DNA methylation on a genome scale.•Other mechanisms appear of more importance to the regulation of genes by vitamin D. It is well-established that vitamin D impacts gene regulation vi...

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Veröffentlicht in:The Journal of steroid biochemistry and molecular biology 2014-05, Vol.141, p.144-149
Hauptverfasser: Chavez Valencia, Raul A., Martino, David J., Saffery, Richard, Ellis, Justine A.
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Sprache:eng
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