Human Noxin is an anti‐apoptotic protein in response to DNA damage of A549 non‐small cell lung carcinoma

Human Noxin (hNoxin, C11Orf82), a homolog of mouse noxin, is highly expressed in colorectal and lung cancer tissues. hNoxin contains a DNA‐binding C‐domain in RPA1, which mediates DNA metabolic processes, such as DNA replication and DNA repair. Expression of hNoxin is associated with S phase in canc...

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Veröffentlicht in:	International journal of cancer 2014-06, Vol.134 (11), p.2595-2604
Hauptverfasser:	Won, Kyoung‐Jae, Im, Joo‐Young, Yun, Chae‐Ok, Chung, Kyung‐Sook, Kim, Young Joo, Lee, Jung‐Sun, Jung, Young‐Jin, Kim, Bo‐Kyung, Song, Kyung Bin, Kim, Young‐Ho, Chun, Ho‐Kyung, Jung, Kyeong Eun, Kim, Moon‐Hee, Won, Misun
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenovirus Animals Apoptosis Apoptosis Regulatory Proteins - genetics Apoptosis Regulatory Proteins - metabolism Biological and medical sciences Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Blotting, Western Cancer Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - pathology Carrier Proteins - genetics Carrier Proteins - metabolism Cell Cycle Cell Proliferation Cells, Cultured Comet Assay Deoxyribonucleic acid DNA DNA damage DNA Damage - physiology DNA Damage - radiation effects DNA repair Flow Cytometry Gene Expression Profiling hNoxin Humans In Situ Hybridization Kinases Lung - cytology Lung - metabolism Lung Neoplasms - genetics Lung Neoplasms - metabolism Lung Neoplasms - pathology Male Medical research Medical sciences Mice Mice, Nude Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Oligonucleotide Array Sequence Analysis p38 Mitogen-Activated Protein Kinases - genetics p38 Mitogen-Activated Protein Kinases - metabolism Phosphoproteins - antagonists & inhibitors Phosphoproteins - genetics Phosphoproteins - metabolism Pneumology Proteins Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction Rhodamines RNA, Messenger - genetics RNA, Small Interfering - genetics target Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Tumors Tumors of the respiratory system and mediastinum Ultraviolet Rays
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