Holocarboxylase synthetase acts as a biotin-independent transcriptional repressor interacting with HDAC1, HDAC2 and HDAC7

In human cells, HCS catalyzes the biotinylation of biotin-dependent carboxylases and mediates the transcriptional control of genes involved in biotin metabolism through the activation of a cGMP-dependent signal transduction pathway. HCS also targets to the cell nucleus in association with lamin-B su...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Molecular genetics and metabolism 2014-03, Vol.111 (3), p.321-330
Hauptverfasser:	Trujillo-Gonzalez, Isis, Cervantes-Roldan, Rafael, Gonzalez-Noriega, Alfonso, Michalak, Colette, Reyes-Carmona, Sandra, Barrios-Garcia, Tonatiuh, Meneses-Morales, Ivan, Leon-Del-Rio, Alfonso
Format:	Artikel
Sprache:	eng
Schlagworte:	Biotin - metabolism Biotin-ligase Carbon-Nitrogen Ligases - genetics Carbon-Nitrogen Ligases - metabolism Chromatin DNA-Binding Proteins - metabolism Drosophila melanogaster Drosophila Proteins - metabolism H3K9met3 Hep G2 Cells Heterochromatin - genetics Histone Deacetylase 1 - genetics Histone Deacetylase 1 - metabolism Histone Deacetylase 2 - genetics Histone Deacetylase 2 - metabolism Histone deacetylases Histone Deacetylases - genetics Histone Deacetylases - metabolism Holocarboxylase synthetase Humans Moonlighting enzyme Promoter Regions, Genetic Transcription Factors - metabolism Transcription, Genetic Transcriptional repression
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!