Mannan-modified adenovirus encoding VEGFR-2 as a vaccine to induce anti-tumor immunity

Purpose Dendritic cell (DC) vaccines are a promising immunotherapeutic approach for treatment and prevention of cancer. While this methodology is widely accepted, it also has some limitations. Antigen-presenting cells including DCs express the mannan receptor (MR). The delivery of a mannan-modified...

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Veröffentlicht in:	Journal of cancer research and clinical oncology 2014-05, Vol.140 (5), p.701-712
Hauptverfasser:	Zhang, Jie, Wang, Ying, Wu, Yang, Ding, Zhen-Yu, Luo, Xin-Mei, Zhong, Wu-Ning, Liu, Jie, Xia, Xiang-Yu, Deng, Guo-Hua, Deng, Yao-Tiao, Wei, Yu-Quan, Jiang, Yu
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae Adenovirus Adenoviruses Angiogenesis Animals Cancer Cancer Research Carcinoma - genetics Carcinoma - immunology Carcinoma - therapy Cell Line, Tumor Dendritic Cells Hematology Humans Immunity, Innate - genetics Immunotherapy Interferon-gamma - genetics Interferon-gamma - immunology Internal Medicine Lung Neoplasms - genetics Lung Neoplasms - immunology Lung Neoplasms - therapy Mannans - immunology Mannans - metabolism Medicine Medicine & Public Health Mice Neovascularization, Pathologic - genetics Neovascularization, Pathologic - therapy Oncology Original Paper Receptors, Mitogen - genetics Receptors, Mitogen - immunology Receptors, Mitogen - metabolism Rodents T-Lymphocytes, Cytotoxic Vaccines Vascular endothelial growth factor Vascular Endothelial Growth Factor Receptor-2 - genetics Vascular Endothelial Growth Factor Receptor-2 - metabolism
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