Acquired chromosomal anomalies in chronic lymphocytic leukemia patients compared with more than 50,000 quasi-normal participants

Pretherapy patients with chronic lymphocytic leukemia (CLL) from US Intergroup trial E2997 were analyzed with single nucleotide polymorphism microarrays to detect acquired chromosomal anomalies. The four CLL-typical anomalies (11q-, +12, 13q-, and 17p-) were found at expected frequencies. Acquired a...

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Veröffentlicht in:	Cancer genetics 2014-01, Vol.207 (1), p.19-30
Hauptverfasser:	Laurie, Cathy C, Laurie, Cecelia A, Smoley, Stephanie A, Carlson, Erin E, Flinn, Ian, Fridley, Brooke L, Greisman, Harvey A, Gribben, John G, Jelinek, Diane F, Nelson, Sarah C, Paietta, Elisabeth, Schaid, Dan, Sun, Zhuoxin, Tallman, Martin S, Weinshilboum, Richard, Kay, Neil E, Shanafelt, Tait D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over cancer precursor condition Case-Control Studies Chromosomal aberration chromosomal mosaic Chromosome Aberrations Chromosome Deletion Chromosome Disorders - genetics Chromosome Mapping chronic lymphocytic leukemia Clinical Trials, Phase III as Topic cytogenetics Female Genome-Wide Association Study Genotype Hematology, Oncology and Palliative Medicine Humans In Situ Hybridization, Fluorescence Leukemia, Lymphocytic, Chronic, B-Cell - genetics Male Medical Education Middle Aged Mosaicism Oligonucleotide Array Sequence Analysis Phenotype Polymorphism, Single Nucleotide Proportional Hazards Models Risk Uniparental Disomy
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