Base Excision Repair of Chemotherapeutically-Induced Alkylated DNA Damage Predominantly Causes Contractions of Expanded GAA Repeats Associated with Friedreich's Ataxia: e93464

Expansion of GAA.TTC repeats within the first intron of the frataxin gene is the cause of Friedreich's ataxia (FRDA), an autosomal recessive neurodegenerative disorder. However, no effective treatment for the disease has been developed as yet. In this study, we explored a possibility of shorten...

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Veröffentlicht in:	PloS one 2014-04, Vol.9 (4)
Hauptverfasser:	Lai, Yanhao, Beaver, Jill M, Lorente, Karla, Melo, Jonathan, Ramjagsingh, Shyama, Agoulnik, Irina U, Zhang, Zunzhen, Liu, Yuan
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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